magnesium sulfate

General Material Information

Preferred name	magnesium sulfate
Trivial Name	Sulfuric acid magnesium salt (1:1)
Short Description	sulfuric acid, magnesium salt (1:1)
Formula	Mg O4 S
CAS Number	7487-88-9
Deleted CAS Number	139939-75-6
ECHA Number	231-298-2
FDA UNII	ML30MJ2U7I
Nikkaji Number	J3.103H
MDL	MFCD00011110
NMR Predictor	External link
Synonyms	epsom salt magnesium sulfate (1:1) magnesium sulphate magnesium(II) sulfate magnesiumsulfate sal angalis sulfate, magnesium sulfuric acid magnesium salt sulfuric acid magnesium salt (1:1) sulfuric acid, magnesium salt sulfuric acid, magnesium salt (1:1) Epsom salts Tomix OT OT-S OT-S (drying agent) Mg-OK MN 00 MG-OK 100 MN 30 Arrosalt 2327 SN 00 M-HOS Magnesii sulfas TC-P MG 3K Epso Top WS 1S NP-YW 1 USN 00 MN 70 SSN 00 MG-N Sunmate MeSH ID: D008278

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Literature & References

	magnesium sulfate
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	7487-88-9
Pubchem (cid):	24083
Pubchem (sid):	134987402

Publications by PubMed
Modified QuEChERS method combined with ultra-high performance liquid chromatography tandem mass spectrometry for the simultaneous determination of 26 mycotoxins in sesame butter.
Use of ammonium formate in QuEChERS for high-throughput analysis of pesticides in food by fast, low-pressure gas chromatography and liquid chromatography tandem mass spectrometry.
Reduction of carcinogenic 4(5)-methylimidazole in a caramel model system: influence of food additives.
Optimization of culture media for large-scale lutein production by heterotrophic Chlorella vulgaris.
Human prokinetic drugs promote gastrointestinal motility in zebrafish.
Multiresidue method for the fast determination of pesticides in nutraceutical products (Camellia sinensis) by GC coupled to triple quadrupole MS.
Rapid multiplug filtration cleanup with multiple-walled carbon nanotubes and gas chromatography-triple-quadruple mass spectrometry detection for 186 pesticide residues in tomato and tomato products.
Response to mold contamination of intravenous magnesium sulfate produced by a compounding pharmacy.
Magnesium enhances exercise performance via increasing glucose availability in the blood, muscle, and brain during exercise.
Single-laboratory validation study of rapid analysis method for multi-class veterinary drugs in milk, fish and shellfish by LC-MS/MS.
[Development of Clostridium perfringens selective chromogenic medium].
Committee Opinion No. 573: Magnesium sulfate use in obstetrics.
Multiplug filtration clean-up with multiwalled carbon nanotubes in the analysis of pesticide residues using LC-ESI-MS/MS.
Description of outbreaks of health-care-associated infections related to compounding pharmacies, 2000-12.
[Validation study on a rapid multi-residue method for determination of pesticide residues in vegetables and fruits by LC-MS/MS].
Preparation and characterization of water-in-oil-in-water emulsions containing a high concentration of L-ascorbic acid.
Multiresidue pesticide analysis of botanical dietary supplements using salt-out acetonitrile extraction, solid-phase extraction cleanup column, and gas chromatography-triple quadrupole mass spectrometry.
Terbium-sensitised luminescence screening method for fluoroquinolones in beef serum.
Optimization of Douchi fibrinolytic enzyme production by statistical experimental methods.
Automated QuEChERS tips for analysis of pesticide residues in fruits and vegetables by GC-MS.
Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.
Enhanced production of bacterial cellulose by using Gluconacetobacter hansenii NCIM 2529 strain under shaking conditions.
Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis.
Effects of temperature and purity of magnesium sulfate during extraction of pesticide residues using the QuEChERS method.
A new and improved strategy combining a dispersive-solid phase extraction-based multiclass method with ultra high pressure liquid chromatography for analysis of low molecular weight polyphenols in vegetables.
Multiresidue pesticide analysis of dried botanical dietary supplements using an automated dispersive SPE cleanup for QuEChERS and high-performance liquid chromatography-tandem mass spectrometry.
The challenges of developing a generic extraction procedure to analyze multi-class veterinary drug residues in milk and honey using ultra-high pressure liquid chromatography quadrupole time-of-flight mass spectrometry.
Rapid determination of nitroimidazole residues in honey by liquid chromatography/tandem mass spectrometry.
Screening assay of residual antibiotics in livestock samples by LC-MS/MS.
Dispersive cleanup of acetonitrile extracts of tea samples by mixed multiwalled carbon nanotubes, primary secondary amine, and graphitized carbon black sorbents.
Optimization of culture medium for enhanced production of exopolysaccharide from Aureobasidium pullulans.
Nitrogen conservation in simulated food waste aerobic composting process with different Mg and P salt mixtures.
Monitoring protein structural changes and hydration in bovine meat tissue due to salt substitutes by Fourier transform infrared (FTIR) microspectroscopy.
Analysis of pesticides residues in fresh produce using buffered acetonitrile extraction and aminopropyl cleanup with gas chromatography/triple quadrupole mass spectrometry, liquid chromatography/triple quadrupole mass spectrometry, gas chromatography/ion trap detector mass spectrometry, and GC with a halogen-specific detector.
Improvement of gel strength and melting point of fish gelatin by addition of coenhancers using response surface methodology.
Analysis of patulin in pear- and apple-based foodstuffs by liquid chromatography electrospray ionization tandem mass spectrometry.
Development of a multi-mycotoxin analysis in beer-based drinks by a modified QuEChERS method and ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
Investigation of the persistence of nitroxynil residues in milk from lactating dairy cows by ultra performance liquid chromatography tandem mass spectrometry.
Multiresidue pesticide analysis by capillary gas chromatography-mass spectrometry.
QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods.
Chemical stability study of vitamins thiamine, riboflavin, pyridoxine and ascorbic acid in parenteral nutrition for neonatal use.
Development of an improved method to extract pesticide residues in foods using acetonitrile with magnesium sulfate and chloroform.
Simultaneous determination of 346 multiresidue pesticides in grapes by PSA-MSPD and GC-MS-SIM.
Influence of NaCl reduction and replacement on the growth of Lactobacillus sakei in broth, cooked ham and white sauce.
Effect of NaCl reduction and replacement on the growth of fungi important to the spoilage of bread.
Extension of the QuEChERS method for pesticide residues in cereals to flaxseeds, peanuts, and doughs.
Determination of phthalates in fruit jellies by dispersive SPE coupled with HPLC-MS.
[Determination of 107 pesticide residues in vegetables using off-line dispersive solid-phase extraction and gas chromatography-tandem mass spectrometry].
[Simultaneous determination of 128 pesticide residues in milk by liquid chromatography-tandem electrospray mass spectrometry].
Sorption of water vapor, hydration, and viscosity of carboxymethylhydroxypropyl guar, diutan, and xanthan gums, and their molecular association with and without salts (NaCl, CaCl2, HCOOK, CH3COONa, (NH4)2SO4 and MgSO4) in aqueous solution.
[Video capsule endoscopy--preliminary experience in university hospital setting].
Multiresidue analysis of 102 organophosphorus pesticides in produce at parts-per-billion levels using a modified QuEChERS method and gas chromatography with pulsed flame photometric detection.
[Determination of 12 azole fungicide residues in beans and corn by offline disperse solid phase extraction and gas chromatography-negative chemical ionization mass spectrometry].
Multiresidue pesticide analysis of wines by dispersive solid-phase extraction and ultrahigh-performance liquid chromatography-tandem mass spectrometry.
[Determination of pesticides in Chinese dumplings using liquid chromatography-tandem mass spectrometry].
Dispersive solid-phase extraction followed by liquid chromatography-tandem mass spectrometry for the multi-residue analysis of pesticides in raw bovine milk.
Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels.
[Determination of triadimenol residue in foods with dispersive solid phase extraction cleanup by gas chromatography-negative chemical ionization mass spectrometry].
A rapid and easy multiresidue method for the determination of pesticide residues in vegetables, fruits, and cereals using liquid Chromatography/tandem mass spectrometry.
[Optimization of plantaricin production by Lactobacillus plantarum ZJ316].
Evaluation of certain food additives and contaminants.
Acute tocolysis for uterine activity reduction in term labor: a review.
A rapid multiresidue method for determination of pesticides in fruits and vegetables by using acetonitrile extraction/partitioning and solid-phase extraction column cleanup.
Simplified pesticide multiresidue analysis of soybean oil by low-temperature cleanup and dispersive solid-phase extraction coupled with gas chromatography/mass spectrometry.
Optimization of production of monacolin K from gamma-irradiated Monascus mutant by use of response surface methodology.
Application of Plackett-Burman experimental design and Doehlert design to evaluate nutritional requirements for xylanase production by Alternaria mali ND-16.
A multistate outbreak of Serratia marcescens bloodstream infection associated with contaminated intravenous magnesium sulfate from a compounding pharmacy.
Determination of pesticide residues in foods by acetonitrile extraction and partitioning with magnesium sulfate: collaborative study.
Ginkgo biloba leaf extract (EGb761) combined with neuroprotective agents reduces the infarct volumes of gerbil ischemic brain.
Multiresidue analytical method using dispersive solid-phase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole blood.
Culture media optimization for growth and phycoerythrin production from Porphyridium purpureum.
Rapid sample preparation method for LC-MS/MS or GC-MS analysis of acrylamide in various food matrices.
[Study on ethanol tolerance of Saccharomyces cerevisiae X330 under very high gravity medium].
DESCRIPTIVE ANALYSIS OF DIVALENT SALTS.
Pesticides and other chemical contaminants.
Evaluation of two fast and easy methods for pesticide residue analysis in fatty food matrixes.
Committee on Residues and Related Topics. Pesticides and other chemical contaminants.
Interlaboratory verified liquid chromatographic method for analysis of vitamins A and E in soy-based infant formula powder.
Uptake of iron by a vegetable; kaiware daikon (Japanese radish sprout).
Timing of magnesium supplementation administered through drinking water to improve fresh and stored pork quality.
Synergistic efficacy of magnesium sulfate and FK506 on cerebral ischemia-induced infarct volume in gerbil.
Two different propionicins produced by Propionibacterium thoenii P-127.
Potential Role of Neuroprotective Agents in the Treatment of Patients with Acute Ischemic Stroke.
Supercritical fluid extraction of pesticides from a table-ready food composite of plant origin (gazpacho).
[Primary approach on midgastric-transverse band modifying the distribution of food between proximal and distal stomach].
Potential Role of Neuroprotective Agents in the Treatment of Patients with Acute Ischemic Stroke.
NTP Toxicology and Carcinogenesis Studies of Polyvinyl Alcohol (CAS No.9002-89-5) in Female B6C3F1 Mice (Intravaginal Studies).
Comparison of magnesium sulfate and sodium sulfate for removal of water from pesticide extracts of foods.
Optimizing detection of heat-injured Listeria monocytogenes in pasteurized milk.
Early feeding after cesarean: randomized trial.
Preparation of bean curds from protein fractions of six legumes.
Mutational analysis of the high-affinity BvgA binding site in the fha promoter of Bordetella pertussis.
New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy.
Development of a simple recovery-enrichment system for enhanced detection of heat-injured Listeria monocytogenes in pasteurized milk.
Isolation, screening and characterization of bacteriocin-producing lactic acid bacteria isolated from traditional fermented food.
Secretion of magnesium and calcium in the total saliva of sheep and its relevance to hypomagnesaemia.
Short time effect of Chemiron (a combination iron preparation), single iron, and different magnesium salts on plasma. Magnesium concentration during early pregnancy in Nigerian women. A preliminary report.
[A study for effects on pre- and postnatal development, including maternal function in rats treated subcutaneously with magnesium sulfate].
[A 4-week toxicity study of magnesium sulfate administered by 24-hr intravenous infusion in beagle dogs].
[A 2-week toxicity study of magnesium sulfate administered by 24-hr intravenous infusion in beagle dogs followed by 2-week recovery period].
[A single dose toxicity study of magnesium sulfate in rats and dogs].
Trehalose 6-phosphate production with energy coupling fermentation by yeast cells.
Magnesium taurate for the prevention and treatment of pre-eclampsia/eclampsia.
Brain ionized magnesium and calcium levels during magnesium supplementation and deficiency in female Long-Evans rats.
Fumonisin B1 production by Fusarium proliferatum strain M5991 in a modified Myro liquid medium.
Magnesium sulfate.
Effects of pH and high ionic strength on the adsorption and activity of native and mutated cellobiohydrolase I from Trichoderma reesei.
Protein-enrichment of wheat bran using Aspergillus terreus.
Magnesium sulfate effects on coliform bacteria reduction in the intestines, ceca, and carcasses of broiler chickens.
Abdominal ultrasonography: improved image quality with the combined use of a diet and laxatives.
Forces involved in adhesion of Bacillus cereus spores to solid surfaces under different environmental conditions.
Measurement of dietary and dentifrice effects upon calculus accumulation rates in the domestic ferret.
[Authorization request for the use of L-carnitine, calcium chloride and magnesium sulfate as nutritional additives in the formulation of food designed for specialized diets].
Selective medium for isolation of Fusarium species and dematiaceous hyphomycetes from cereals.
Methods of euthanasia in poultry and food-producing animals.
Liquid chromatographic determination of vitamins D2 and D3 in fortified milk and infant formulas.
Application of gel permeation chromatography and nonaqueous reverse phase chromatography to high performance liquid chromatographic determination of retinyl palmitate and alpha-tocopheryl acetate in infant formulas.
Tibial dyschondroplasia in broilers: comparison to dietary additives and strains.
Sodium intake reduction in volunteer families by using a salt substitute and nutrition counselling.
[Diagnosis of the Zollinger-Ellison syndrome].
Growth characteristics of a new methylomonad.
Effect of magnesium and some nutrients on the growth and nuclease formation of a moderate halophile, Micrococcus varians var. halophilus.
A method for determining "true" availability of magnesium from foodstuffs using chickens.
[Bile secretion during feeding and introduction of food into the duodenum in relation to the functional condition of the digestive tract at different stages of its periodic activity].
Effects of oral magnesium sulphate on colonic motility in patients with the irritable bowel syndrome.
Discrepancies in the enumeration of Escherichia coli.
Acidity, osmolality, electrolyte and amino acid concentration of casein-hydrolysate and synthetic amino acid solutions.
Isolation of mutants of Candida tropicalis with increased methionine content.
Publications by J-Stage
Effects of Magnesium Sulfate on the Luminescence of Vibrio fischeri under Nutrient-Starved Conditions

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2833.21.0000
FDA Listing of Food Additive Status:	View
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: •...magnesium sulfate most common forms are the crystallized salt mgso4.7h2o (epsom salt) & kieserite (mgso4.h2o). when either of these salts is calcined to remove combined water, the anhydrous salt, mgso4, is obtained. •magnesium sulfate injection, usp, is avail in concn of 10, 12.5, 25 & 50%. mgso4 injection •grades: technical, cp, usp, fcc •purity: 62-70%. magnesium sulfate, dried british pharmacopeia •emejo contains 80-82% mgso4 •acs grade available

Suppliers

Allan Chemical	American Elements
American International Chemical, LLC.	Camden-Grey Essential Oils
Covalent Chemical	Dow Chemical
ECSA Chemicals	Glentham Life Sciences
Jost Chemical	Kraft Chemical
Krunal Group	Penta International
Sigma-Aldrich: Aldrich	Wedor Corporation
Penta International Corporation

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	120.36679840088
Specific gravity	@ 25 °C
Pounds per Gallon
Vapor Pressure	3.4E-5 mmHg @ 25 °C
Flash Point TCC Value	N/a
logP (o/w)	-1.031 est
Solubility
water, 1.401e+005 mg/L @ 25 °C (est)	Yes

Organoleptic Properties

Odor Type: Odorless
Odor strength	none
General comment	At 100.00 %. odorless
Flavor Type: Salty
salty, bitter
General comment	Salty bitter

Potential Uses

Applications	cosmetic agents dietary supplements
Other purposes	Viscosity controlling agents
Cosmetic purposes	Bulking agents , Hair conditioning , Viscosity controlling agents

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1029 mg/kg Farmakologiya i Toksikologiya Vol. 10, Pg. 107, 1975. intraperitoneal-dog LDLo 1200 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. oral-man TDLo 428 mg/kg BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Japanese Journal of Toxicology. Vol. 2, Pg. 285, 1989. intravenous-mouse LDLo 48 mg/kg Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962. oral-mouse LDLo 5000 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. oral-rabbit LDLo 3000 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935.
Dermal Toxicity:
subcutaneous-rat LD50 1200 mg/kg Neuroscience Letters. Vol. 117, Pg. 207, 1990. subcutaneous-mouse LD50 645 mg/kg Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 7, Pg. 178, 1986. subcutaneous-cat LDLo 1000 mg/kg BEHAVIORAL: GENERAL ANESTHETIC American Journal of Physiology. Vol. 14, Pg. 366, 1905. subcutaneous-dog LDLo 1500 mg/kg "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1364, 1935. subcutaneous-guinea pig LDLo 1800 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: GENERAL ANESTHETIC American Journal of Physiology. Vol. 14, Pg. 366, 1905. subcutaneous-rabbit LDLo 1750 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) American Journal of Physiology. Vol. 14, Pg. 366, 1905.
Inhalation Toxicity:
Not determined

Safety in use information

Category:
cosmetic agents, dietary supplements
Recommendation for magnesium sulfate usage levels up to:
	not for fragrance use.

Recommendation for magnesium sulfate flavor usage levels up to:
	not for flavor use.