diisopropyl adipate

General Material Information

Preferred name	diisopropyl adipate
Trivial Name	Diisopropyl adipate
Short Description	dipropan-2-yl hexanedioate
Formula	C12 H22 O4
CAS Number	6938-94-9
Deleted CAS Number	121879-14-9
FEMA Number	4474
ECHA Number	230-072-0
FDA UNII	P7E6YFV72X
Nikkaji Number	J14.488F
Beilstein Number	1785346
MDL	MFCD00026391
xLogP3-AA	2.20 (est)
Bio Activity Summary	External link
NMR Predictor	External link
JECFA Food Flavoring	1966 diisopropyl adipate
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	6938-94-9 ; DIISOPROPYL ADIPATE
Synonyms	iso adipate (Symrise) adipic acid diisopropyl ester adipic acid isopropyl ester adipic acid, diisopropyl ester ceraphyl 230 crodamol DA dermol DIA dipropan-2-yl hexanedioate hallstar DIPA hexane dioic acid 1,6-bis(1-methyl ethyl) ester hexane dioic acid bis(1-methyl ethyl) ester hexanedioic acid 1,6-bis(1-methylethyl) ester hexanedioic acid bis(1-methylethyl) ester hexanedioic acid, bis (1-methylethyl) ester hexanedioic acid, bis(1-methylethyl) ester hexanedioic acid,1,6-bis(1-methylethyl) ester bis(1-methyl ethyl) hexane dioate bis(1-methylethyl) hexanedioate bis(1-methylethyl)hexanedioate nikkol DID 1,6-bis( propan-2-yl) hexanedioate schercemol DIA schercemol DIA ester standamul DIPA tegester 504-D wickenol 116 Hexanedioic acid, 1,6-bis(1-methylethyl) ester Isopropyl adipate NSC 56587 Iso Adipat Crodamol DA-LQ-(JP) Hexanedioic acid diisopropyl ester Pelemol DIA Isoadipate FineNeo-DIA

Publications by PubMed
Development of transdermal therapeutic formulation of CNS5161, a novel NMDA receptor antagonist, by utilizing pressure-sensitive adhesives II: improved transdermal absorption and evaluation of efficacy and safety.
Conductive microemulsions for template CoNi electrodeposition.
Iterative tandem catalysis of secondary diols and diesters to chiral polyesters.
Investigation of fatty acid esters to replace isopropyl myristate in the sterility test for ophthalmic ointments.
Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin.
Final report on the safety assessment of Stearamide DIBA-Stearate.
Simultaneous optimization based on artificial neural networks in ketoprofen hydrogel formula containing O-ethyl-3-butylcyclohexanol as percutaneous absorption enhancer.
Tacrolimus ointment improves psoriasis in a microplaque assay.
Effect of vehicles on diclofenac permeation across excised rat skin.
Percutaneous absorption of retinoids: influence of vehicle, light exposure, and dose.
Interaction of indomethacin with the vehicle component diisopropyl adipate.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C14523
HMDB (The Human Metabolome Database):	HMDB41613
FooDB:	FDB021768
Export Tariff Code:	2917.12.5000
ChemSpider:	View
FAO:	Diisopropyl adipate

Allan Chemical	Alzo International
American International Chemical, LLC.	Axsyn
BOC Sciences	Charkit Chemical
Chemical-navi - Nikkol	Croda
HallStar	Inoue Perfumery
Lubrizol Corporation	Penta International
Santa Cruz Biotechnology	Sigma-Aldrich: Aldrich
Symrise	SysKem Chemie
TCI AMERICA	Universal Preserv-A-Chem Inc.
American International Chemical, Inc.	Charkit Chemical Corporation
Penta International Corporation	Symrise AG

Material listed in food chemical codex	No
Molecular weight	230.30413818359
Specific gravity	@ 20 °C
Pounds per Gallon	8.022 to 8.064
Refractive Index	1.423 to 1.427 @ 20 °C
Boiling Point	251 to 253°C @ 760 mm Hg
Acid Value	1 max KOH/g
Vapor Pressure	0.019 mmHg @ 25 °C
Flash Point TCC Value	109.44 °C TCC
logP (o/w)	2.676 est
Solubility
alcohol	Yes
water, 55.61 mg/L @ 25 °C (est)	Yes

Applications	food-contact surface of paper and paperboard
Other purposes	Emollients, Plasticisers, Skin conditioning, Solvents
Cosmetic purposes	Fragrance, Plasticisers, Skin conditioning, Skin conditioning - emollient, Solvents

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 640 mg/kg U.S. Army, Chemical Corps Medical Laboratories Research Reports. Vol. #256, Pg. 1954
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Category:
food-contact surface of paper and paperboard
Recommendation for diisopropyl adipate usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		200.00000	400.00000
beverages(nonalcoholic):		0.10000	2.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-