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acesulfame potassium

Chemical Structure

General Material Information

Preferred name acesulfame potassium
Trivial Name Acesulfame potassium
Short Description potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide
Formula C4 H4 K N O4 S
CAS Number 55589-62-3
ECHA Number 259-715-3
FDA UNII 23OV73Q5G9
Nikkaji Number J269.091H
MDL MFCD00043833
NMR Predictor External link
FDA Mainterm 55589-62-3 ; ACESULFAME POTASSIUM
Synonyms
  • ace K
  • acesulfame K
  • 6-methyl-1,2,3-oxathiazin-4 -one2,2-dioxidepotassiumsalt
  • 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide potassium salt
  • 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide, potassium salt
  • 6-methyl-1,2,3-oxathiazin-4(3H)-one2,2-dioxidepotassiumsalt
  • 6-methyl-3H-1,2,3-oxathiazine-2,2,4-trione, potassium salt
  • 1,2,3-oxathiazin-4-ol, 6-methyl-, 2,2-dioxide, potassium salt (1:1)
  • 1,2,3-oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt
  • potassium 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide
  • potassium 6-methyl-2,2-dioxooxathiazin-4-olate
  • potassium 6-methyl-4-oxo-4H-1,2,3-oxathiazin-3-ide 2,2-dioxide
  • potassium acesulfame
  • potassium salt of 3,4-dihydro-6-methyl-1,2,3-oxathiazine-4-one-2,2-dioxide
  • potassium salt of 6-methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide
  • 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt (1:1)
  • 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt
  • Sunett
  • 6-Methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt
  • Sunnett
  • Otizon
  • E 950
  • Sweet One
  • Potassium acesulfamate
  • Sunett D
  • Sunnet Pharma Grade D
  • Ace-K
  • Potassium acetosulfame

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

potassium 6-methyl-2,2-dioxooxathiazin-4-olate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:55589-62-3
Pubchem (cid):23683747
Pubchem (sid):135019383
Publications by PubMed
Spatial characteristics of professional tennis serves with implications for serving aces: A machine learning approach.
Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans.
[Development of a New Method for Determination of Sodium Saccharin and Acesulfame Potassium with the Aid of Coagulant].
Nonnutritive Sweeteners in Breast Milk.
[Association between non-nutritive sweeteners and obesity risk among university students in Latin America].
Simultaneous determination of sweeteners in beverages by LC-MS/MS.
[Consumption of carbonated beverages with nonnutritive sweeteners in Latin American university students].
Acesulfame-K and pharmaceuticals as co-tracers of municipal wastewater in a receiving river.
Quantification of acesulfame potassium in processed foods by quantitative 1H NMR.
Allergic reaction caused by acesulfame potassium in foods.
[Modification of fasting blood glucose in adults with diabetes mellitus type 2 after regular soda and diet soda intake in the State of Querétaro, Mexico].
Precise measurement for the purity of amino acid and peptide using quantitative nuclear magnetic resonance.
Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists.
Effects of three intense sweeteners on fat storage in the C. elegans model.
[A rapid dialysis method for analysis of artificial sweeteners in food].
[Comprehensive evaluation of palatability for commercial medicine by taste sensing system].
A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.
Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.
Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.
Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice.
Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31.
Effect of sweeteners and hydrocolloids on quality attributes of reduced-calorie carrot juice.
Lack of functionally active sweet taste receptors in the jejunum in vivo in the rat.
Validation of the Korean Addenbrooke's Cognitive Examination for diagnosing Alzheimer's dementia and mild cognitive impairment in the Korean elderly.
Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue.
Effect of the artificial sweetener, acesulfame potassium, a sweet taste receptor agonist, on glucose uptake in small intestinal cell lines.
Anticonvulsant activity of artificial sweeteners: a structural link between sweet-taste receptor T1R3 and brain glutamate receptors.
Metabolic acidosis mimicking diabetic ketoacidosis after use of calorie-free mineral water.
Angiotensin I-converting enzyme inhibitory proteins and peptides from the rhizomes of Zingiberaceae plants.
Inhibitory activities of baicalin against renin and angiotensin-converting enzyme.
[Simultaneous determination of six food additives in meat products by high performance liquid chromatography].
Rational development of taste masked oral liquids guided by an electronic tongue.
An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.
Inadequate toxicity tests of food additive acesulfame.
General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats.
Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
NTP toxicology studies of acesulfame potassium (CAS No. 55589-62-3) in genetically modified (FVB Tg.AC Hemizygous) mice and carcinogenicity studies of acesulfame potassium in genetically modified [B6.129-Trp53(tm1Brd) (N5) Haploinsufficient] mice (feed studies)mice.
Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2.
Exploratory studies to investigate a linked prebiotic origin of RNA and coded peptides. 3rd communication. Behaviour of 5-amino-1H-imidazole-4-carbonitrile derivatives.
Testing needed for acesulfame potassium, an artificial sweetener.
Action mechanism of an angiotensin I-converting enzyme inhibitory peptide derived from chicken breast muscle.
[Analysis of nine kinds of sweeteners in foods by LC/MS].
Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone.
Scope of the reductive aldol reaction: application to aromatic carbocycles and heterocycles.
The powder flow and compact mechanical properties of sucrose and three high-intensity sweeteners used in chewable tablets.
Determination of acesulfame and sucralose in oral electrolyte maintenance solution by liquid chromatography.
[Simultaneous determination of various food additives by high performance liquid chromatography].
Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans.
Noncariogenic intense natural sweeteners.
Gustatory neural coding in the monkey cortex: the quality of sweetness.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB33955
FooDB:FDB012173
Export Tariff Code:2934.99.9000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 201.24298095703
Boiling Point 332 to 334°C @ 760 mm Hg
Vapor Pressure 1.0E-6 mmHg @ 25 °C
Flash Point TCC Value 155 °C TCC
logP (o/w) -0.31 est
Solubility
water, 1e+006 mg/L @ 25 °C (est) Yes
alcohol, very slightly Yes
alcohol No

Organoleptic Properties

Odor Type: Odorless
Odor strength none
General comment At 100.00 %. odorless
Flavor Type: Sweet
sweet, sugar, candy
General comment Sweet sugar candy

Potential Uses

Applications
Other purposes Masking agents, Oral care agents, Sweetener
Cosmetic purposes Fragrance

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
sweeteners, flavor enhancers
Recommendation for acesulfame potassium usage levels up to:
not for fragrance use.

Safety references

European Food Safety Authority (EFSA) reference(s):

Safety of the proposed extension of use of acesulfame K (E 950) in foods for special medical purposes in young children
View page or View pdf

Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23683747
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
potassium 6-methyl-2,2-dioxooxathiazin-4-olate
Chemidplus:0055589623