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malic acid
General Material Information
| Preferred name | malic acid |
| Trivial Name | Malic acid |
| Short Description | DL-malic acid |
| Formula | C4 H6 O5 |
| CAS Number | 6915-15-7 |
| Deleted CAS Number | 617-48-1 |
| Flavis Number | 8.017 |
| ECHA Number | 230-022-8 |
| FDA UNII | 817L1N4CKP |
| Nikkaji Number | J3.091K |
| Beilstein Number | 1723539 |
| MDL | MFCD00064212 |
| COE Number | 17 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| FDA Mainterm | 617-48-1 ; MALIC ACID |
| Synonyms |
|
US / EU / FDA / JECFA / FEMA / Scholar / Patents
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| Perfumer & Flavorists | Start search |
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| NCBI | Start search |
Literature & References
| 2-hydroxybutanedioic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 6915-15-7 |
| Pubchem (cid): | 525 |
| Pubchem (sid): | 134987363 |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00711 |
| HMDB (The Human Metabolome Database): | HMDB00744 |
| FooDB: | FDB012047 |
| FDA Listing of Food Additive Status: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| FAO: | DL-MALIC ACID |
| Formulations/Preparations: •uva ursi, this is volatile oil containing a glucoside, arbutin, tannin, & gallic & malic acids. •grades: technical, active and inactive; fcc. the natural material is levorotatory, but the synthetic material is optically inactive •food grade: powder, fine granular, and granular •granules and powder grades | |
Suppliers
PhysChem Properties
| Material listed in food chemical codex | Yes |
| Molecular weight | 134.08781433105 |
| Melting Point | 131 to 135°C @ 760 mm Hg |
| Boiling Point | 306 to 307°C @ 760 mm Hg |
| Vapor Pressure | 7.1E-5 mmHg @ 25 °C |
| Vapor Density | 4.6 |
| Flash Point TCC Value | 153.33 °C TCC |
| logP (o/w) | -1.37 est |
| Solubility | |
| water, 1000000 mg/L @ 20 °C (exp) | Yes |
Organoleptic Properties
| Odor Type: Odorless | |
| Odor strength | none |
| General comment | At 100.00 %. odorless |
| Flavor Type: Acidic | |
| acidic | |
| General comment | Strong acidic |
Occurrences
| (data available) |
Safety Information
Safety information
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
| R 22 - Harmful if swallowed. R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| oral-rat LD50 3500 mg/kg (Morgareidge, 1973a) oral-mouse LD50 2660 mg/kg (Morgareidge, 1973b) oral-rabbit LD50 3000 mg/kg (Morgareidge, 1973c) intraperitoneal-mouse LD50 50 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982. oral-mouse LD50 1600 mg/kg Kodak Company Reports. Vol. #82-0458 intraperitoneal-rat LD50 100 mg/kg "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| flavoring agents and adjuvants, curing and pickling agents, flavor enhancers | |||
| Recommendation for malic acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 13000.00 (μg/capita/day) | ||
Safety references
| European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
| Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
| Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) View page or View pdf |
| 22nd list of substances for food contact materials View page or View pdf |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009) View page or View pdf |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium, Magnesium and Zinc Malate added for nutritional purposes to food supplements as sources for Calcium, Magnesium and Zinc and to Calcium Malate added for nutritional purposes to foods for particular nutritional uses and foods intended for the general population as source for Calcium View page or View pdf |
| Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy View page or View pdf |
| Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list View page or View pdf |
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):6915-15-7 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :525 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:1 |
| 2-hydroxybutanedioic acid |
| Chemidplus:0006915157 |
| RTECS:ON7175000 for cas# 6915-15-7 |