hotrienol

Hotrienol, also known by its chemical name (E,R)-3,7-dimethyl-1,5,7-octatrien-3-ol, is a natural organic compound belonging to the class of sesquiterpenoid alcohols. It appears as a colorless or pale liquid with a molecular formula of C₁₀H₁₆O and a molar mass of approximately 152.24 g/mol. The compound exhibits distinct sensory characteristics, prominently a medium-strength tropical odor with sweet, fennel, and ginger nuances, along with fresh floral flavor notes. Hotrienol is found naturally in a variety of essential oils and plant materials including bois de rose leaf oil from Brazil, elderflower, laurel leaf oil, lavandin oil, as well as in fruits like peach, nectarine, grapefruit, and passion fruit. For further chemical and biological data, hotrienol is indexed in public chemical databases such as PubChem. This compound is typically sourced via extraction from natural plant materials where it contributes to the characteristic aromatic profile.

Hotrienol occurs naturally in various essential oils such as those derived from bois de rose leaf, laurel leaves, and lavandin, as well as in fruits like grapefruit, peach, nectarine, and passion fruit. It is reported in beverages including brandy, plum brandy, and cognac. This compound applies primarily as a flavor and fragrance agent, where its tropical and floral olfactory qualities enhance product aroma and taste. Hotrienol's use is governed by standards such as FEMA (US), ensuring appropriate safety and usage levels. It is utilized in formulations that benefit from its sweet, woody, and tropical notes, including perfumes, fine fragrances, and food flavorings where a fresh, natural accent is desired.

Hotrienol is a moderately lipophilic sesquiterpenoid alcohol with a molecular weight of 152.24 g/mol and the formula C₁₀H₁₆O. It presents a boiling point range of 229 to 230 °C at atmospheric pressure (760 mm Hg), indicating moderate volatility suitable for fragrance use. The compound's specific gravity ranges from 0.877 to 0.884 at 25 °C, while its refractive index lies between 1.458 and 1.468 at 20 °C. Hotrienol has an estimated logP value of about 2.4, denoting moderate lipophilicity favorable for solubility in alcohol-based solvents but limited water solubility, approximately 406.5 mg/L at 25 °C. Its vapor pressure is low at 0.014 mmHg at 25 °C, supporting moderate persistence in air. The flash point is measured at 193 °F (89.4 °C), which is relevant for handling and storage safety. These physical and chemical properties influence its performance and stability in flavors and fragrances where it imparts characteristic tropical and floral aromas.

Leffingwell:	Chirality or Article
	(5E)-3,5-dimethylocta-1,5,7-trien-3-ol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	6433750
Pubchem (sid):	134994818
Flavornet:	20053-88-7

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB014436
YMDB (Yeast Metabolome Database):	YMDB01714
Typical G.C.
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for hotrienol usage levels up to:
	2.0000 % in the fragrance concentrate.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :6433750

National Institute of Allergy and Infectious Diseases:Data

(5E)-3,5-dimethylocta-1,5,7-trien-3-ol

Chemidplus:0020053887