indolall

Indolall is a complex fragrance compound resulting from the condensation reaction between 7-hydroxy-3,7-dimethyloctanal and 1H-indole. It appears as a substance with molecular formula C18H27NO2 and molecular weight approximately 289.42 g/mol. Synonyms include indolam 50 (IFF) and indole hydroxycitronellal condensation products. This compound exhibits a unique olfactory profile characterized by floral, jasmine-like notes combined with a subtle animalic tone. It is widely used in perfumery to enhance floral absolutes such as jasmine by contributing fixative properties and increasing scent substantivity. Indolall is referenced in chemical databases like PubChem, linking to detailed chemical and safety data. The compound is typically derived through specialized synthetic processes that join hydroxycitronellal and indole units.

Indolall is not found naturally but is synthesized for use in fragrance formulations. Its primary application is in the flavor and fragrance industry as a fixative agent, enhancing the longevity and stability of floral scent profiles, particularly jasmine, lilac, and hyacinth fragrances. The compound's animalic and floral odor qualities make it suitable for complex perfumes requiring both narcotic floral and subtle animal-like notes. According to IFRA (Global) standards, indolall is allowed at usage levels up to 5% in fragrance concentrates. It is not recommended for use in flavorings. Its fixative function supports the stability and substantivity of perfume compositions, making it valuable in high-end cosmetic and personal care products.

Indolall exhibits moderate vapor pressure of approximately 0.00318 mmHg at 25°C, indicating low volatility which supports its role as a fixative in fragrances. It has a predicted logP value near 1.54, suggesting moderate lipophilicity and solubility in organic solvents such as alcohol; it is poorly soluble in water but soluble in alcohols. The flash point is reported at 219°F, indicative of low flammability under typical handling conditions. Stability assessments confirm its compatibility with various formulation bases including alcoholic lotions, shampoos, soaps, detergents, and fabric softeners. These physicochemical properties facilitate its integration into diverse fragrance systems where controlled release and scent persistence are desired.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Acute toxicity, Oral (Category 4), H302 Skin irritation (Category 2), H315 Skin sensitisation (Category 1), H317 Serious eye damage/eye irritation (Category 2A), H320
GHS Label elements, including precautionary statements
Pictogram
Signal word	Warning
Hazard statement(s)
H302 - Harmful if swallowed H315 - Causes skin irritation H317 - May cause an allergic skin reaction H320 - Causes eye irritation
Precautionary statement(s)
P102 - Keep out of reach of children. P103 - Read label before use P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P264 - Wash skin thouroughly after handling. P270 - Do not eat, drink or smoke when using this product. P280 - Wear protective gloves/protective clothing/eye protection/face protection. P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302 + P352 - IF ON SKIN: wash with plenty of soap and water. P330 - Rinse mouth. P337 + P313 - IF eye irritation persists: Get medical advice/attention. P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for indolall usage levels up to:
	5.0000 % in the fragrance concentrate.
Recommendation for indolall flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):68908-82-7

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :163281

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

7-hydroxy-3,7-dimethyloctanal; 1H-indole

Chemidplus:0068908827

8,8-di(indol-1-yl)-2,6-dimethyloctan-2-ol

Chemidplus:067801369