(R)-sandal hexanol

(R)-sandal hexanol is a bicyclic alcohol characterized by the molecular formula C₁₆H₂₈O. It appears as a colorless liquid with a clean, sweet woody aroma reminiscent of sandalwood, placing it in the category of fragrance compounds. Known by synonyms including 4-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yl)cyclohexanol and 4-((1R,2R,4R)-born-2-yl) cyclohexanol, it is linked in chemical databases [such as PubChem](https://pubchem.ncbi.nlm.nih.gov/compound/106674). This compound is typically derived through synthetic routes mimicking natural sandalwood constituents, which contributes to its application scope in fragrance formulations.

(R)-sandal hexanol is not widely reported as naturally occurring in biological sources, but it serves a significant role as a synthetic fragrance ingredient. Its primary application is as a woody and sandalwood-scented fragrance agent in perfumery. This molecule is often employed to impart clean balsamic woody notes and can replace or enhance natural sandalwood scents in formulations. According to IFRA (Global) standards, it is recognized within fragrance ingredient guidelines, though it is not approved for flavor use. Potential odor profiles linked to (R)-sandal hexanol include amber, ambergris, cedar, and various floral and woody accords, supporting its use in complex scent blends.

(R)-sandal hexanol has an estimated molecular weight of approximately 236.4 g/mol and presents moderate hydrophobicity with a logP estimate around 5.06, indicating substantial lipophilicity. Its flash point is about 273 °F (134 °C), suggesting reasonable thermal stability under normal handling conditions. The compound exhibits limited water solubility, approximately 1.693 mg/L at 25 °C, but it is soluble in alcohols, making it compatible with typical organic solvents used in fragrance formulations. Its bicyclic structure confers a relatively rigid conformation, which can influence volatility and diffusion characteristics, important for its sensory perception in formulated products.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for (R)-sandal hexanol flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

EPA Substance Registry Services (TSCA):66072-32-0

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :106674

National Institute of Allergy and Infectious Diseases:Data

4-(1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl)cyclohexan-1-ol

Chemidplus:0066072320