2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carboxaldehyde

2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carboxaldehyde is a sulfur heterocyclic compound characterized by the molecular formula C₁₂H₂₀OS. It appears as a colorless or slightly yellow liquid and is recognized for its distinctive green and fruity odor profile, often described as reminiscent of green mango and cassis with savory and spicy undertones. This compound is also known by synonyms including 2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carbaldehyde and 3,6-dihydro-2,6-dipropyl-2H-thiopyran-5-carboxaldehyde. Its structural details and chemical information are cataloged under PubChem (CID 71396131). This flavoring substance is typically synthesized for use in food formulations to impart complex aroma notes and is not naturally derived from biological sources.

2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carboxaldehyde does not occur naturally in notable quantities but is commonly utilized as a synthetic flavoring agent. Its potent green and fruity odor characteristics enable its application in diverse food products, including nonalcoholic and alcoholic beverages, chewing gum, confectionery frostings, frozen dairy, jams, and sweet sauces. The compound’s inclusion in formulations is governed by guidelines such as those issued by FEMA (US), which classify it under GRAS (Generally Recognized As Safe) flavoring substances, with defined usage levels to ensure safety. The flavor compound enhances sensory qualities by adding fresh, tropical, and complex aromatic nuances to the finished products.

This compound has a molecular weight of approximately 212.36 g/mol and a moderately hydrophobic nature indicated by an estimated XLogP value of 3.40. It demonstrates limited water solubility, measured at around 16.88 mg/L at 25 °C, suggesting preferential solubility in organic solvents suitable for flavor formulation. The physicochemical profile supports its stability and effectiveness in lipid-rich and aqueous food matrices at typical usage levels. Its sulfur atom within the thiopyran ring contributes to the characteristic odor and flavor nuances. These properties collectively influence its volatility, interaction with other flavor components, and sensory impact in complex food systems.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
VCF-Online:	VCF Volatile Compounds in Food

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carboxaldehyde usage levels up to:
	not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 28
Click here to view publication 28
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		0.05000	5.00000
beverages(alcoholic):		0.03000	10.00000
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		10.00000	100.00000
condiments / relishes:		-	-
confectionery froastings:		0.30000	30.00000
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		0.50000	50.00000
fruit ices:		0.05000	5.00000
gelatins / puddings:		0.20000	10.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		0.50000	50.00000
imitation dairy:		0.05000	5.00000
instant coffee / tea:		0.05000	5.00000
jams / jellies:		0.50000	20.00000
meat products:		-	-
milk products:		0.05000	5.00000
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		0.05000	5.00000
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		0.50000	20.00000
snack foods:		-	-
soft candy:		0.20000	5.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		0.20000	10.00000

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :71396131

National Institute of Allergy and Infectious Diseases:Data

2,6-dipropyl-5,6-dihydro-2H-thiopyran-3-carbaldehyde

Chemidplus:0061407009