endo-1,2,3,3-tetramethyl bicyclo(2.2.1)heptan-2-ol

endo-1,2,3,3-tetramethyl bicyclo(2.2.1)heptan-2-ol is a bicyclic tertiary alcohol known also as methyl fenchol and humus ether (Takasago). It contains eleven carbon atoms and one oxygen atom with the molecular formula C₁₁H₂₀O and a molecular weight of approximately 168.28 g/mol. This compound exhibits a medium-strength, vegetal, green mossy odor which makes it valued in the flavor and fragrance industry. The bicyclo[2.2.1]heptane skeleton provides a unique structural framework contributing to its olfactory profile. It is synthetically derived and can be linked to its PubChem entry (CID 119965) for further chemical information. Its sources are chiefly synthetic, aiming to replicate natural mossy nuances in perfumery formulations.

endo-1,2,3,3-tetramethyl bicyclo(2.2.1)heptan-2-ol does not naturally occur in significant biological systems but is manufactured for its valued scent properties. It finds applications primarily as a fragrance ingredient in perfume compositions, where it enhances naturalness and diffusion especially in floral and green accords, even at trace levels. Due to its stable and distinctive green-mossy odor, it is broadly employed in high-quality perfuming agents. The IFRA (Global) standard has issued usage level recommendations that restrict its concentration to a maximum of 0.1% in fragrance concentrates to ensure consumer safety and regulatory compliance. It is not recommended or used for flavor applications.

This compound has a moderate boiling range between 208 and 209°C at standard atmospheric pressure. Its estimated partition coefficient (logP) of around 2.9 indicates lipophilic characteristics suitable for fragrance diffusion and moderate volatility. The vapor pressure is low at 0.049 mmHg at 25°C, supporting its substantivity in formulations with more than 24 hours longevity at full concentration. solubility data suggest it dissolves well in alcohol solvents but has limited solubility in water, consistent with its hydrophobic bicyclic structure. The flash point is approximately 82°C (182°F), indicating relatively safe handling under typical conditions used in perfumery manufacture. These physicochemical traits directly influence its formulation stability, scent release, and compatibility with other ingredients.

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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for endo-1,2,3,3-tetramethyl bicyclo(2.2.1)heptan-2-ol usage levels up to:
	0.1000 % in the fragrance concentrate.
Recommendation for endo-1,2,3,3-tetramethyl bicyclo(2.2.1)heptan-2-ol flavor usage levels up to:
	not for flavor use.

Safety references

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EPA Substance Registry Services (TSCA):28462-85-3

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :119965

National Institute of Allergy and Infectious Diseases:Data

(1R,3R,4R)-2,2,3,4-tetramethylbicyclo[2.2.1]heptan-3-ol

Chemidplus:0028462853