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2-methoxy-6-methyl pyrazine

Chemical Structure

General Material Information

Preferred name 2-methoxy-6-methyl pyrazine
Trivial Name 2-Methoxy-6-methylpyrazine
Short Description 2-methoxy-6-methylpyrazine
Formula C6 H8 N2 O
CAS Number 2882-21-5
FEMA Number 3183
Flavis Number 14.025
ECHA Number 220-737-3
FDA UNII 18565KT6V3
Nikkaji Number J143.096C
COE Number 2266
Bio Activity Summary External link
NMR Predictor External link
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
Synonyms
  • 5-methoxy-3-methyl pyrazine
  • 5-methoxy-3-methylpyrazine
  • 2-methoxy-6-methylpyrazine
  • 2-methyl-6-methoxypyrazine
  • pyrazine, 2-methoxy-6-methyl-
  • 2-Methoxy-6-methylpyrazine
  • 2-Methyl-6-methoxypyrazine

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB40143
FooDB:FDB019840
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 124.14295959473
Boiling Point 170 to 171°C @ 760 mm Hg
Vapor Pressure 1.931 mmHg @ 25 °C
Flash Point TCC Value 62.22 °C TCC
logP (o/w) 1.29
Solubility
alcohol Yes
water, 7665 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Nutty
hazelnut roasted hazelnut, almond roasted almond, peanut roasted peanut
General comment At 0.10 % in propylene glycol. roasted hazelnut almond peanut

Potential Uses

Applications
Odor purposes Tobacco
Flavoring purposes Almond, Bread, Burnt, Chicory root, Chocolate cocoa, Coffee, Meat, Nut, Peanut, Potato, Rum

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2-methoxy-6-methyl pyrazine usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 2.20 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 15.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
average usual ppmaverage maximum ppm
baked goods: -4.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -2.00000
fruit ices: -2.00000
gelatins / puddings: -2.00000
granulated sugar: --
gravies: --
hard candy: -4.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):2882-21-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :520395
National Institute of Allergy and Infectious Diseases:Data
2-methoxy-6-methylpyrazine
Chemidplus:0002882215