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hydrocortisone acetate

Chemical Structure

General Material Information

Preferred name hydrocortisone acetate
Trivial Name Hydrocortisone acetate
Short Description 21-(acetyl oxy)-11,17-pregn-4-ene-3,20-dione
Formula C23 H32 O6
CAS Number 50-03-3
Deleted CAS Number 42016-02-4
ECHA Number 200-004-4
FDA UNII 3X7931PO74
Nikkaji Number J4.096G
Beilstein Number 2066841
MDL MFCD00037714
Bio Activity Summary External link
NMR Predictor External link
Synonyms
  • ab bocort
  • abbocort
  • acepolcort-H
  • acetate-AS
  • aceto-cort
  • 21-( acetyl oxy)-11,17-pregn-4-ene-3,20-dione
  • 21-O- acetylcortisol
  • alfacorton
  • allocort
  • bacicoline
  • bambicort
  • berlison
  • biocortar
  • caldecort
  • carmol HC
  • carmol-HC
  • chemysone
  • chloromycetin hydrocortisone ophthalmic
  • clear-aid
  • colifoam
  • collusul-HC
  • colofoam
  • cortacream
  • cortaid
  • cortef acetate
  • cortell
  • cortes
  • corti
  • crema transcutan
  • crematranscutan
  • derminovag
  • dermosa hidrocortisona
  • [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
  • dricort
  • efcolin
  • efcorlin
  • efzem
  • ekzemsalbe F
  • epifoam
  • fenitral
  • fernisone
  • glycocortison
  • hemsol-HC
  • hipokort
  • hycor eye oitment
  • hycortole acetate
  • hyderm
  • hydrin-2
  • hydrison
  • hydrocal
  • 17a- hydrocorticosterone-21-acetate
  • hydrocortisat
  • hydrocortison
  • hydrocortisone 21-acetate
  • hydrocortistab
  • hydrocortole acetate
  • hydrocortone acetate
  • hydrosone
  • 17-hydroxycorticosterone 21-acetate
  • 17-a- hydroxycorticosterone 21-acetate
  • hydroxycorticosterone acetate
  • 17-a- hydroxycorticosterone acetate
  • 17-hydroxycorticosterone, 21-acetate
  • hysone-A
  • idrocort
  • iracetisone
  • korti
  • lanacort
  • latimit
  • lenirit
  • lidaform-HC
  • lidamantle-HC
  • mantadil
  • medithane
  • micort-HC
  • ophticor
  • orabase HCA
  • pabracort
  • pannocort
  • pregn-4-ene-3, 20-dione, 11b,17,21-trihydroxy-, 21-acetate
  • pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11b)-
  • pregn-4-ene-3,20-dione, 11-b,17,21-trihydroxy-, 21-acetate
  • pregn-4-ene-3,20-dione, 11b,17,21-trihydroxy-, 21-acetate
  • pregn-4-ene-3,20-dione, 21-(acetoxy)-11,17-dihydroxy-, (11-b)-
  • iso pto-hydrocortisone
  • resicort
  • sagittacortin
  • sanadermil
  • sigma cort
  • sigmacort
  • siguent hycor
  • sintotrat
  • soenol hydrocortison
  • squibb-HC
  • supralef
  • urecortyn
  • velopural
  • wycort
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11β)-
  • Cortisol acetate
  • Cortisol, 21-acetate
  • (11β)-21-(Acetyloxy)-11,17-dihydroxypregn-4-ene-3,20-dione
  • 21-Acetoxy-11β,17α-dihydroxypregn-4-ene-3,20-dione
  • Cortril acetate
  • HA
  • Hydrin 2
  • 17-Hydroxycorticosterone 21-acetate
  • Isopto-Hydrocortisone
  • 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
  • 21-Acetoxy-11β,17-dihydroxypregn-4-ene-3,20-dione
  • 21-Acetoxy-11β,17-dihydroxypregn-4-en-3,20-dione
  • 17α-Hydroxycorticosterone acetate
  • Berlison F
  • Proctocort
  • Hc 45
  • Cortril acetate AS
  • Anusol HC
  • Cordes
  • Cortifoam
  • NSC 741
  • Corticaine
  • Hydrocort acetate
  • 4-Pregnene-11β,17,21-triol-3,20-dione 21-acetate

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C02821
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 404.50323486328
Flash Point TCC Value 196.2 °C TCC
logP (o/w) 2.19
Solubility
water, 38.71 mg/L @ 25 °C (est) Yes
water, 14.1 mg/L @ 25 °C (exp) Yes

Safety Information

Safety information

Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 2300 mg/kg
Compilation of LD50 Values of New Drugs.

Dermal Toxicity:
subcutaneous-mouse LD50 45050 ug/kg
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986

subcutaneous-rat LDLo 250 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
pharmaceuticals / chemical synthisis
Recommendation for hydrocortisone acetate usage levels up to:
not for fragrance use.
Recommendation for hydrocortisone acetate flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5744
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Chemidplus:0000050033
RTECS:GM8960000 for cas# 50-03-3