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General Material Information

Preferred name vanilmandelic acid
Trivial Name Vanillylmandelic acid
Short Description hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
Formula C9 H10 O5
CAS Number 55-10-7
Deleted CAS Number 2394-20-9
FEMA Number 4660
Flavis Number 8.134
ECHA Number 200-224-0
FDA UNII 0DQI268449
Nikkaji Number J27.583B
Beilstein Number 2213227
MDL MFCD00004235
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 2020 hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 55-10-7 ; HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID
Synonyms
  • benzeneacetic acid, a,4-dihydroxy-3-methoxy-
  • alpha-4-dihydroxy-3-methoxybenzeneacetic acid
  • 4-hydroxy 3-methoxymandelic acid
  • 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
  • DL-4-hydroxy-3-methoxy mandelic acid
  • 4-hydroxy-3-methoxy-DL-mandelic acid
  • (±)-4-hydroxy-3-methoxymandelic acid
  • 4-hydroxy-3-methoxymandelic acid
  • dextro,laevo-4-hydroxy-3-methoxymandelic acid
  • DL-4-hydroxy-3-methoxymandelic acid
  • 4-hydroxy-3-methoxymandelicacid
  • 4-hydroxy-3-methoxyphenyl(hydroxy)acetic acid
  • (4-hydroxy-3-methoxyphenyl) glycolic acid
  • (4-hydroxy-3-methoxyphenyl)glycolic acid
  • hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
  • mandelic acid, 4-hydroxy-3-methoxy-
  • 3-methoxy-4-hydroxyphenylhydroxyacetic acid
  • nibovan
  • vanillinemandelic acid
  • vanillomandelic acid
  • vanillyl mandelic acid
  • vanillylmandelic acid
  • (±)- vanillylmandelic acid
  • (±)- vanilmandelic acid
  • Benzeneacetic acid, α,4-dihydroxy-3-methoxy-
  • α,4-Dihydroxy-3-methoxybenzeneacetic acid
  • HMMA
  • 4-Hydroxy-3-methoxymandelic acid
  • VMA
  • Vanillinmandelic acid
  • (4-Hydroxy-3-methoxyphenyl)glycolic acid
  • 3-Methoxy-4-hydroxyphenylhydroxyacetic acid
  • 4′-Hydroxy-3′-methoxymandelic acid
  • DL-3-Methoxy-4-hydroxymandelic acid
  • DL-Vanillylmandelic acid
  • 4-Hydroxy-3-methoxy-DL-mandelic acid
  • (±)-3-Methoxy-4-hydroxymandelic acid
  • DL-4-Hydroxy-3-methoxymandelic acid
  • dl-4-Hydroxy-3-methoxymandelic acid (dl-vanillylmandelic acid)
  • (±)-4-Hydroxy-3-methoxymandelic acid
  • DL-Vanillomandelic acid
  • (±)-Vanilmandelic acid
  • Vanillyl-dl-mandelic acid
  • 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
  • 2-(4′-Hydroxy-3′-methoxyphenyl)-2-hydroxyethanoic acid
  • MeSH ID: D014642

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C05584
HMDB (The Human Metabolome Database):HMDB00291
FooDB:FDB021931
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
FAO:Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 198.17469787598
Flash Point TCC Value 173.33 °C TCC
logP (o/w) -0.212 est
Shelf life 12 months (or longer if stored properly.)
Storage notes Refrigerate in tightly sealed containers.
Solubility
alcohol, slightly Yes
water, slightly Yes
water, 4.267e+005 mg/L @ 25 °C (est) Yes

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for vanilmandelic acid usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 120.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 5000 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
average usual ppmaverage maximum ppm
baked goods: 10.0000020.00000
beverages(nonalcoholic): 5.0000010.00000
beverages(alcoholic): 10.0000020.00000
breakfast cereal: 10.0000020.00000
cheese: --
chewing gum: 5.0000010.00000
condiments / relishes: --
confectionery froastings: 10.0000020.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 10.00000100.00000
fruit ices: 10.0000020.00000
gelatins / puddings: 20.0000050.00000
granulated sugar: --
gravies: --
hard candy: 5.0000010.00000
imitation dairy: 10.0000020.00000
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 10.0000050.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: 10.0000020.00000
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 10.0000050.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 10.00000100.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000020.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 10.0000020.00000
Bakery wares (07.0): 10.0000020.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 10.0000020.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000010.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000020.00000
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 20.0000050.00000

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):55-10-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1245
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
Chemidplus:0000055107