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2-(2-ethoxyethyl) pyridine
2-(2-ethoxyethyl) pyridine is a pyridine derivative notable for its bitter, astringent flavor and moderate volatility, identified by CAS number 28672-54-0.
General Material Description
2-(2-ethoxyethyl) pyridine is an organic chemical compound classified as a pyridine derivative, featuring the molecular formula C9H13NO. It presents as a liquid substance with characteristic bitter and astringent flavor notes, attributed to its pyridine core and ethoxyethyl substituent. Synonyms for this compound include pyridine, 2-(2-ethoxyethyl)-, and NSC 163912. This compound is referenced in chemical databases such as the PubChem repository. It is primarily synthesized for research and industrial purposes rather than derived directly from natural sources. The compound’s sensory attributes are bitter and basic, distinguishing it from many flavor-active pyridines.
Occurrence, Applicability & Potential Uses
2-(2-ethoxyethyl) pyridine occurs mainly as a synthetic intermediate or research chemical rather than a natural product. It has documented applications limited to informational contexts, without authorized use in flavors or fragrances. This restriction is underscored by its absence from flavoring agent databases and safety recommendations advising against its use in consumable flavors. Under the REACH regulation (European Union), its registration allows monitoring but does not confer approval for flavor or fragrance inclusion. Research interest may focus on its chemical reactivity or physicochemical profile rather than practical formulation use.
Physico-Chemical Properties Summary
2-(2-ethoxyethyl) pyridine displays physicochemical properties indicative of moderate volatility and solubility characteristics relevant to formulation and handling. It has an estimated log P value of 1.18, suggesting moderate hydrophobicity combined with partial aqueous solubility. Its vapor pressure at 25 °C is approximately 0.4 mmHg, consistent with a volatile organic compound. The flash point is reported as 163 °F (approximately 73.9 °C), indicating flammability hazards require awareness during handling. These properties collectively affect storage, transport, and potential application environments, and they must guide risk assessment protocols and containment strategies.
FAQ
What is 2-(2-ethoxyethyl) pyridine and what are its basic characteristics?
2-(2-ethoxyethyl) pyridine is an organic compound classified as a pyridine derivative with a molecular formula of C9H13NO. It features a bitter and astringent flavor note and is recognized by its CAS number 28672-54-0. The compound exists mainly in research contexts and displays moderate volatility and solubility in water. Common synonyms include pyridine, 2-(2-ethoxyethyl)- and NSC 163912.
Where is 2-(2-ethoxyethyl) pyridine used and how does it occur naturally or industrially?
2-(2-ethoxyethyl) pyridine is predominantly a synthetic chemical not occurring naturally in significant amounts. Its uses are informational and industrial research-related rather than for flavoring or fragrance applications, as regulatory guidance advises against such uses. The compound is produced via chemical synthesis routes involving pyridine derivatives, serving mainly as an intermediate or chemical research substance.
What regulations apply to 2-(2-ethoxyethyl) pyridine and how is it sourced safely?
This compound is subject to registration and monitoring under the REACH regulation within the European Union, which manages chemical safety and environmental impact. It is not approved for use in fragrances or food flavors, and recommended flavor or fragrance usage levels are zero, reflecting safety precautions. Safety data sheets indicate no classified hazards under OSHA rules, but appropriate chemical handling practices are advised. Reliable sourcing requires attention to purity specifications and adherence to regulatory compliance standards.
US / EU / FDA / JECFA / FEMA / Scholar / Patents
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Literature & References
| 2-(2-ethoxyethyl)pyridine | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 98758 |
| Pubchem (sid): | 135055288 |
| Publications by US Patents | |
| 3,952,024 - Furfurylthioacetone | |
Other Information
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| ChemSpider: | View |
General Material Information
| Preferred name | 2-(2-ethoxyethyl) pyridine |
| Trivial Name | 2-(2-Ethoxyethyl)pyridine |
| Short Description | pyridine, 2-(2-ethoxyethyl)- |
| Formula | C9 H13 N O |
| CAS Number | 28672-54-0 |
| ECHA Number | 249-140-6 |
| FDA UNII | X9650F9KG5 |
| Nikkaji Number | J250.754D |
| MDL | MFCD00023548 |
| Bio Activity Summary | External link |
| NMR Predictor | External link |
| Synonyms |
|
Suppliers
| Sigma-Aldrich: Aldrich |
PhysChem Properties
| Material listed in food chemical codex | No |
| Molecular weight | 151.20881652832 |
| Vapor Pressure | 0.4 mmHg @ 25 °C |
| Flash Point TCC Value | 72.5 °C TCC |
| logP (o/w) | 1.18 est |
| Solubility | |
| water, 6.843e+004 mg/L @ 25 °C (est) | Yes |
Organoleptic Properties
| Flavor Type: Bitter | |
| bitter, astringent | |
| General comment | Bitter, astringent, basic |
Safety Information
Safety information
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in use information
| Category: | |||
| information only not used for fragrances or flavors | |||
| Recommendation for 2-(2-ethoxyethyl) pyridine usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for 2-(2-ethoxyethyl) pyridine flavor usage levels up to: | |||
| not for flavor use. | |||
Safety references
| EPI System: View |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :98758 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-(2-ethoxyethyl)pyridine |
| Chemidplus:0028672540 |