(R)-(-)-lilyall

(R)-(-)-lilyall, known chemically as benzenepropanal, 4-(1,1-dimethylethyl)-a-methyl-, (aR)-, is a synthetic aromatic aldehyde with the molecular formula C₁₄H₂₀O. It typically appears as a colorless to pale yellow liquid, exhibiting a distinctive floral odor reminiscent of lily of the valley. This compound, also referenced under synonyms like (2R)-3-(4-tert-butylphenyl)-2-methylpropanal, is widely utilized in the fragrance industry for its soft, fresh, and clean scent qualities. It can be sourced through chemical synthesis from petrochemical precursors, designed to replicate natural floral notes. For chemical entity referencing, it corresponds to PubChem CID 1549660. Its distinctive olfactory profile makes it a preferred ingredient in perfumes and scented consumer products.

(R)-(-)-lilyall does not occur naturally but is synthesized for use as a fragrance agent in perfumery and personal care products. It imparts a fresh floral note typical of lily of the valley, contributing to the top or middle fragrance accords. This compound is especially valued for its ability to provide a clean and delicate floral scent in complex fragrance formulations. According to IFRA (Global) standards, usage levels and safety have been evaluated to ensure consumer protection in fragranced products. It is not used in flavor applications. Its utilization is thus confined primarily to cosmetic and fine fragrance sectors, leveraging its sensory characteristics while adhering to established regulatory frameworks.

(R)-(-)-lilyall exhibits a molecular weight of approximately 204.3 g/mol and has a calculated logarithm of the partition coefficient (logP) value near 4.07, indicating moderate lipophilicity. It is a liquid at room temperature with poor water solubility, estimated at around 7.86 mg/L at 25 °C, yet it is readily soluble in alcohol solvents common in fragrance bases. Its flash point is relatively high, around 121 °C (250 °F), suggesting stability under typical formulation and storage conditions. The molecule contains an aromatic ring substituted with bulky groups contributing to its physicochemical stability and characteristic odor. These properties influence its handling, blending, and volatility when formulated in complex aromatic products.

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Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for (R)-(-)-lilyall flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

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Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :1549660

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

(2R)-3-(4-tert-butylphenyl)-2-methylpropanal

Chemidplus:0075166313