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norstictic acid

Chemical Structure

General Material Information

Preferred name norstictic acid
Trivial Name Norstictic acid
Short Description 7H-2,6,12-trioxabenzo[5,6]cyclohept[1,2-e]indene-11-carboxaldehyde, 1,3-dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo-
Formula C18 H12 O9
CAS Number 571-67-5
FDA UNII Search
Nikkaji Number J53.078F
MDL MFCD02113777
xLogP3-AA 2.40 (est)
Bio Activity Summary External link
NMR Predictor External link
Applications
  • natural substances and extractives
Synonyms
  • bryopogonic acid
  • 1,3- dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo-7H-isobenzofuro(4,5-b)(1,4)benzodioxepin-11-carboxaldehyde
  • 1,3- dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo07H-isobenzofuro(4,5-b)(1,4)benzodioxepin-11-carboxaldehyde
  • 1,4,10- trihydroxy-5,8-dimethyl-3,7-dioxo-1,3-dihydro-7H-2,6,12-trioxabenzo[5,6]cyclohepta[1,2-e]indene-11-carbaldehyde
  • 7H-2,6,12- trioxabenzo[5,6]cyclohept[1,2-e]indene-11-carboxaldehyde, 1,3-dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo-
  • 7H-Isobenzofuro[4,5-b][1,4]benzodioxepin-11-carboxaldehyde, 1,3-dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo-
  • 1,3-Dihydro-1,4,10-trihydroxy-5,8-dimethyl-3,7-dioxo-7H-isobenzofuro[4,5-b][1,4]benzodioxepin-11-carboxaldehyde

Potential Uses

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5379540
Pubchem (sid):135229553
Publications by PubMed
Norstictic Acid Inhibits Breast Cancer Cell Proliferation, Migration, Invasion, and In Vivo Invasive Growth Through Targeting C-Met.
The Parmotrema acid test: a look at species delineation in the P. perforatum group 40 y later.
Anticancer activities of selected species of North American lichen extracts.
A new depside from Usnea aciculifera growing in Vietnam.
A New Species of Graphis and New Lichen Records from Vietnam, Including a Second Worldwide Report of Sarcographina cyclospora.
Biological activities and chemical composition of lichens from Serbia.
Comparative metabolite profiling and chemical study of Ramalina siliquosa complex using LC-ESI-MS/MS approach.
Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents.
Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.
A new depsidone and antibacterial activities of compounds from Usnea undulata Stirton.
Ionic liquids based microwave-assisted extraction of lichen compounds with quantitative spectrophotodensitometry analysis.
Characterisation of phenols and antioxidant and hypolipidaemic activities of Lethariella cladonioides.
Chemical Composition, Antioxidant, and Antimicrobial Activities of Lichen Umbilicaria cylindrica (L.) Delise (Umbilicariaceae).
Analysis of salazinic, norstictic, and usnic acids in Xanthoparmelia chlorochroa by ultra-performance liquid chromatography/tandem mass spectrometry.
Optimization of a microwave-assisted extraction of secondary metabolites from crustose lichens with quantitative spectrophotodensitometry analysis.
Antimycobacterial activity of lichen substances.
Evaluation of the antimicrobial activity of the acetone extract of the lichen Ramalina farinacea and its (+)-usnic acid, norstictic acid, and protocetraric acid constituents.
Light might regulate divergently depside and depsidone accumulation in the lichen Parmotrema hypotropum by affecting thallus temperature and water potential.
New Record of Karoowia saxeti (Stizenb.) Hale in South Korea.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 372.28643798828
Flash Point TCC Value 283.7 °C TCC
logP (o/w) 2.33 est
Solubility
water, 8.089 mg/L @ 25 °C (est) Yes

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
natural substances and extractives
Recommendation for norstictic acid usage levels up to:
not for fragrance use.
Recommendation for norstictic acid flavor usage levels up to:
not for flavor use.

Safety references

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5379540
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0000571675