laevo-menthone 1,2-glycerol ketal

General Material Information

Preferred name	laevo-menthone 1,2-glycerol ketal
Trivial Name	[(6S,9R)-9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl]methanol
Formula	C13 H24 O3
CAS Number	563187-91-7
FEMA Number	3807
Flavis Number	6.133
FDA UNII	Search
xLogP3-AA	2.50 (est)
NMR Predictor	External link
JECFA Food Flavoring	445 (-)-menthone 1,2-glycerol ketal
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	977178-02-1 ; L-MENTHONE 1,2-GLYCEROL KETAL
Synonyms	frescolat MGA (-)- menthone 1,2-glycerol ketal L- menthone 1,2-glycerol ketal laevo- menthone glycerin acetal L- menthone glycerine acetal laevo- menthone glycerine acetal L- menthone glycerol ketal L-9-methyl-6-(1-methyl ethyl)-1,4-dioxaspiro(4.5)decane-2-methanol laevo-9-methyl-6-(1-methyl ethyl)-1,4-dioxaspiro(4.5)decane-2-methanol [(6S,9R)-9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl]methanol L-6-6-iso propyl-9-methyl-1,4-dioxaspiro(4.5)decane-2-methanol laevo-6-6-iso propyl-9-methyl-1,4-dioxaspiro(4.5)decane-2-methanol

Leffingwell:	Chirality or Article
	[(6S,9R)-9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl]methanol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	9964606
Pubchem (cas):	563187-91-7

Publications by Google Patents
Enhanced flavors using menthone ketals
Publications by PubMed
Design of novel multifunctional targeting nano-carrier drug delivery system based on CD44 receptor and tumor microenvironment pH condition.
[(2R,5R,6S,9R)-6-Isopropyl-9-methyl-1,4-dioxaspiro-[4.5]decan-2-yl]methyl 4-bromo-benzoate.
A 3,5-dinitro-benzoyl derivative of a stereoisomer of glycerol menthonide.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
HMDB (The Human Metabolome Database):	HMDB32367
FooDB:	FDB009779
FDA Listing of Food Additive Status:	View

H. Interdonati, Inc.	Jiangyin Healthway
Parchem	Synerzine
Jiangyin Healthway International Trade Co., Ltd	Synerzine, Inc.

Material listed in food chemical codex	No
Molecular weight	228.33187866211
Solubility
water, 27.28 mg/L @ 25 °C (est)	Yes

Odor Type: Odorless
General comment	Odorless
Mosciano, Gerard P&F 25, No. 6, 26, (2000)	At 10.00 %. Little or no odor
Flavor Type: Cooling
clean, cooling
Mosciano, Gerard P&F 25, No. 6, 26, (2000)	At 5.00 - 100.00 ppm. A clean crisp coolness on palate starting out low but growing. The coolness is readily apparent in the throat. A slight tingling or burning sensation accompanies the coolness


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Category:
flavor enhancers
Recommendation for laevo-menthone 1,2-glycerol ketal usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 17
Click here to view publication 17
		average usual ppm	average maximum ppm
baked goods:		50.00000	80.00000
beverages(nonalcoholic):		10.00000	15.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		500.00000	800.00000
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		50.00000	80.00000
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :9964606

National Institute of Allergy and Infectious Diseases:Data

[(6S,9R)-9-methyl-6-propan-2-yl-1,4-dioxaspiro[4.5]decan-3-yl]methanol