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cyclopropane carboxylic acid (2-isopropyl-5-methyl cyclohexyl) amide

General Material Information

Trivial Name cyclopropane carboxylic acid (2-isopropyl-5-methyl cyclohexyl) amide
Short Description cyclopropanecarboxylic acid (2-isopropyl-5-methylcyclohexyl)-amide
Formula C14 H25 N O
CAS Number 958660-02-1
CAS Number 958660-04-3
FEMA Number 4558
Flavis Number 16.115
FDA UNII 4G2NYA84QJ
xLogP3-AA 3.50 (est)
NMR Predictor External link
JECFA Food Flavoring 2006 cyclopropanecarboxylic acid (2-isopropyl-5-methylcyclohexyl)-amide
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 977188-03-6 ; CYCLOPROPANECARBOXYLIC ACID (2-ISOPROPYL-5-METHYL-CYCLOHEXYL)-AMIDE
Synonyms
  • cyclopropanecarboxylic acid (1R,2R,5S)-(2-isopropyl-5-ethylcyclohexyl)-amide
  • cyclopropanecarboxylic acid (1S,2S,5R)-(2-isopropyl-5-ethylcyclohexyl)-amide
  • cyclopropanecarboxylic acid (2-isopropyl-5-methylcyclohexyl)-amide
  • N-[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]cyclopropanecarboxamide
  • N-(2-iso propyl-5-methylcyclohexyl)cyclopropanecarboxamide

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Parchem

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 223.35945129395
Solubility
water, 10.14 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Savory
savory, brothy, umami
General comment At 0.10 % in propylene glycol. mild savory brothy umami

Safety Information

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50 [sex: F] > 2000 mg/kg
(Vaeth, 2007)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor enhancers
Recommendation for cyclopropane carboxylic acid (2-isopropyl-5-methyl cyclohexyl) amide usage levels up to:
not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 3.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 960 (μg/person/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24. Update in publication number(s): 26
Click here to view publication 24
average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): 0.200001.70000
beverages(alcoholic): --
breakfast cereal: --
cheese: 2.000006.00000
chewing gum: 10.0000050.00000
condiments / relishes: 4.0000010.00000
confectionery froastings: 1.0000020.00000
egg products: 4.0000010.00000
fats / oils: 2.000008.00000
fish products: 2.000008.00000
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: 4.0000010.00000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 2.000008.00000
milk products: --
nut products: --
other grains: --
poultry: 2.000008.00000
processed fruits: --
processed vegetables: 2.000008.00000
reconstituted vegetables: --
seasonings / flavors: 10.0000020.00000
snack foods: 8.0000020.00000
soft candy: --
soups: 4.0000010.00000
sugar substitutes: --
sweet sauces: --
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 2.000006.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.000008.00000
Edible ices, including sherbet and sorbet (03.0): --
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): 2.000008.00000
Confectionery (05.0): --
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): 2.000008.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.000008.00000
Eggs and egg products (10.0): 4.0000010.00000
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 10.0000020.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.70000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): 8.0000020.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 300 (FGE.300): One cyclo-aliphatic amide from chemical group 33
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 300, Revision 1 (FGE.300Rev1): One cyclo-aliphatic amide from chemical group 33
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :58004815
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
N-[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]cyclopropanecarboxamide
Chemidplus:0958660021
N-[(1R,2R,5S)-5-methyl-2-propan-2-ylcyclohexyl]cyclopropanecarboxamide
Chemidplus:0958660043