ethyl alpha-ethyl-beta-methyl-beta-phenyl glycidate

Ethyl alpha-ethyl-beta-methyl-beta-phenyl glycidate is a synthetic organic ester classified chemically as an oxirane carboxylate with molecular formula C14H18O3. It appears as a liquid substance with a characteristic sweet fruity berry and jammy aroma, making it valuable in flavor and fragrance formulations. Known also by several synonyms such as ethyl (E)-2-ethyl-3-methyl-3-phenyl oxirane-2-carboxylate, this compound is referenced under FEMA (Flavor and Extract Manufacturers Association) number 4653 and JECFA (Joint FAO/WHO Expert Committee on Food Additives) number 2143. It is typically obtained via chemical synthesis and is not naturally occurring, widely used to impart fruity notes in various consumer goods. Its entry in public chemical databases like PubChem provides detailed chemical and safety information.

This compound is not found naturally but is manufactured specifically for use as a flavor and fragrance agent. Its fruity and berry-like sensory properties allow it to enhance or impart sweet, vibrant notes in foods, beverages, and personal care products. It is utilized in formulations for chewing gum, nonalcoholic beverages, confections, and gelatins, with typical concentration limits established by FEMA (US) to ensure safety and consistency. The substance complies with standards such as IFRA (International Fragrance Association) (Global) guidelines, governing use levels in perfumes and cosmetic applications. Its incorporation in flavor systems delivers complex fruity nuances, complementing other aroma chemicals in diverse product categories.

Ethyl alpha-ethyl-beta-methyl-beta-phenyl glycidate exhibits melting points ranging from 37 to 42°C and boiling points between 295 and 297°C at standard atmospheric pressure (760 mm Hg). Its vapor pressure is very low, about 0.001 mmHg at 25°C, indicating low volatility under ambient conditions. The estimated partition coefficient (log P) is approximately 3.5, reflecting moderate hydrophobicity. It is soluble in alcohol solvents but has limited solubility in water, with an estimated aqueous solubility of 12.33 mg/L at 25°C. The compound’s flash point is reported at 248°F (approximately 120°C), consistent with its use as a stable ingredient in fragrant and flavor formulations. These properties affect its evaporation rate, blending behavior, and compatibility in various media.

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		0.10000	5.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		5.00000	50.00000
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		0.30000	5.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		1.00000	20.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :569008

National Institute of Allergy and Infectious Diseases:Data

ethyl 2-ethyl-3-methyl-3-phenyloxirane-2-carboxylate

Chemidplus:0019464949