ferrous ascorbate

General Material Information

Preferred name	ferrous ascorbate
Trivial Name	Ferrous ascorbate
Short Description	iron(2+) di-L-ascorbate
Formula	C12 H16 Fe O12 +2
CAS Number	24808-52-4
ECHA Number	246-469-7
FDA UNII	DI3477D0PI
MDL	MFCD00137682
NMR Predictor	External link
FDA Mainterm	24808-52-4 ; FERROUS ASCORBATE
Applications	nutrient supplements
Synonyms	L- ascorbic acid iron(2+) salt (2:1) laevo- ascorbic acid iron(2+) salt (2:1) (2R)-2-[(1S)-1,2- dihydroxyethyl]-4,5-dihydroxyfuran-3-one; iron(2+) ferrous cevitamate iron(2+) di-L-ascorbate iron(2+) di-laevo-ascorbate iron(II) ascorbate Ferrate(2-), bis[L-ascorbato(2-)-κO2,κO3]-, hydrogen (1:2) L-Ascorbic acid, iron(2+) salt (2:1) Ferrate(2-), bis[L-ascorbato(2-)-O2,O3]-, dihydrogen Ferrate(2-), bis[L-ascorbato(2-)-κO2,κO3]-, dihydrogen L-Ascorbic acid, iron complex Ferro-ascorbate Ascofer Complefer Fe-Vit Ferro Grad Nedifer Bis[[(2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-yl]oxy]iron Iron(II) L-ascorbate

Potential Uses

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Literature & References

	(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; iron(2+)
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	62785
Pubchem (sid):	135019915

Publications by PubMed
Efficacy and safety of ferrous asparto glycinate in the management of iron deficiency anaemia in pregnant women.
Different iron sources to study the physiology and biochemistry of iron metabolism in marine micro-algae.
Is a 40 % absorption of iron from a ferrous ascorbate reference dose appropriate to assess iron absorption independent of iron status?
Iron deficiency anemia in pregnancy: intravenous versus oral route.
Bioavailability of stabilised ferrous gluconate with glycine in fresh cheese matrix: a novel iron compound for food fortification.
Treatment of iron deficiency anemia in children: a comparative study of ferrous ascorbate and colloidal iron.
Evaluation of efficacy and tolerability of RB Tone forte tablet in the treatment of pregnancy anaemia.
Antiurolithic effect of berberine is mediated through multiple pathways.
Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism.
Cooperative functions of manganese and thiol redox system against oxidative stress in human spermatozoa.
Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents.
Iron absorption and iron status are reduced after Roux-en-Y gastric bypass.
Antioxidant-mediated protective effect of potato peel extract in erythrocytes against oxidative damage.
Iron chelators and free radical scavengers in naturally occurring polyhydroxylated 1,4-naphthoquinones.
Effect of ferrous sulphate and ascorbic acid on motility, viability and lipid peroxidation of crossbred cattle bull spermatozoa.
Oxidative stress alters membrane sulfhydryl status, lipid and phospholipid contents of crossbred cattle bull spermatozoa.
Phytochemical analysis of Achyranthes aspera and its activity on sesame oil induced lipid peroxidation.
Persistent anemia after Roux-en-Y gastric bypass.
Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells.
Echinochrome, a naturally occurring iron chelator and free radical scavenger in artificial and natural membrane systems.
Breast milk fractions solubilize Fe(III) and enhance iron flux across Caco-2 cells.
Role of some trace metal ions in placental membrane lipid peroxidation.
Bioavailability of iron bis-glycinate chelate in water.
Hypocholesterolemic and hypolipidemic activity of some novel morpholine derivatives with antioxidant activity.
Effect of genetically modified, low-phytic acid maize on absorption of iron from tortillas.
[Effect of altitude on iron absorption].
Microencapsulated ferrous sulfate to fortify cow milk: absorption and distribution in mice.
Bioavailability, absorption mechanism, and toxicity of microencapsulated iron (I) sulfate: studies in mice.
A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols.
Milk inhibits and ascorbic acid favors ferrous bis-glycine chelate bioavailability in humans.
Ferrous-ascorbate complexes as carriers of nitric oxide.
Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice.
Bioavailability and stability of microencapsulated ferrous sulfate in fluid milk: studies in mice.
[Results of preoperative autotransfusion with ferrous ascorbate prophylaxis in orthopedic surgery patients].
Effects of iron replenishment on iron, calcium, phosphorus and magnesium metabolism in iron-deficient rats.
Effects of membrane peroxidation on [3H]acetylcholine release in rat cerebral cortical synaptosomes.
Rate of 59Fe uptake into brain and cerebrospinal fluid and the influence thereon of antibodies against the transferrin receptor.
Inhibitory effect of phosphatidylserine on iron-dependent lipid peroxidation.
Bioavailability and the mechanisms of intestinal absorption of iron from ferrous ascorbate and ferric polymaltose in experimental animals.
Mechanisms of transport of nontransferrin-bound iron in basolateral and canalicular rat liver plasma membrane vesicles.
[Oral iron therapy. Bioavailability and therapeutic effectiveness of ferrous iron in effervescent tablets in posthemorrhagic iron deficiency anemia].
Lipid peroxidation of human granulocytes (PMN) and monocytes by iron complexes.
Haemoglobin-fortified cereal: an alternative weaning food with high iron bioavailability.
Studies on Fe complexes produced by yeast. IV. Mechanism of Fe transport from an Fe(II)-oligosaccharide complex across the mucosal membrane of the rat intestine.
Effect of iron on polymorphonuclear granulocyte phagocytic capacity: role of oxidation state and effect of ascorbic acid.
Lipid peroxidation of rabbit small intestinal microvillus membrane vesicles by iron complexes.
Intervention in free radical mediated hepatotoxicity and lipid peroxidation by indole-3-carbinol.
Relationship between absorption of inorganic and food iron in field studies.
Long-term consumption of beef extended with soy protein by children, women and men: III. Iron absorption by adult men.
Failure of transferrin to enhance iron absorption in achlorhydric human subjects.
Complex stability of ferrous ascorbate in aqueous solution and its significance for iron absorption.
Anaerobic iron uptake by Escherichia coli.
Mucosal uptake, mucosal transfer and retention of a therapeutic dose of iron.
Studies on the binding of iron by rabbit intestinal microvillus membranes.
Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: enhanced lipid peroxidation potential in vitro.
A preliminary simulated iron fortification trial in South Indian preschool children.
Ageing of Neurospora crassa. VIII. Lethality and mutagenicity of ferrous ions, ascorbic acid, and malondialdehyde.
The measurement of food iron absorption in man. A methodological study on the measurement of dietary non-haem-Fe absorption when the subjects have a free choice of food items.
Sodium iron NaFeEDTA as an iron fortification compound in Central America. Absorption studies.
An animal model to study iron availability from human diets.
Iron absorption from Southeast Asian diets. II. Role of various factors that might explain low absorption.
Patterns of food iron absorption in iron-deficient white and indian subjects and in venesected haemochromatotic patients.
Iron absorption from Southeast Asian rice-based meals.
Iron absorption from food and from ferrous ascorbate. A study in normal subjects, patients with peptic ulcer and patients after partial gastrectomy.
Iron absorption from ferrous ascorbate in normal male subjects and in patients 3-6 years after antrectomy with gastroduodenostomy.
[Orbital scintigraphy using ferrous ascorbate labelled with technetium 99 m. Value in the diagnosis of intraorbital expansive tumors].
A scintiscan study of renal form and function using technetium-labelled ferrous ascorbate.
[Labeled ferrous ascorbate. II. Study of renal uptake].
[Labelled ferrous ascorbate. I. Value in renal scintography].
[Morphological and functional renal studies using scintigraphy with technetium ferrous ascorbate].
[Hydroxylation of 11-desoxycorticosterone by oxygen ion-ferrous ascorbate model system].

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB017533
FDA Listing of Food Additive Status:	View
ChemSpider:	View
EFSA Update of results on the monitoring of furan levels in food:	Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:	Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:	Read Report

Suppliers

American Elements	BOC Sciences
Global Calcium	Santa Cruz Biotechnology
Sigma-Aldrich: Sigma

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	408.09490966797
Vapor Pressure	0 mmHg @ 25 °C
Flash Point TCC Value	180.4 °C TCC
logP (o/w)	-2.653 est
Solubility
water, 1e+006 mg/L @ 25 °C (est)	Yes

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
nutrient supplements
Recommendation for ferrous ascorbate usage levels up to:
	not for fragrance use.

Recommendation for ferrous ascorbate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :62785

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one; iron(2+)

Chemidplus:0024808524