methyl syringate

General Material Information

Preferred name	methyl syringate
Trivial Name	Methyl syringate
Short Description	benzoic acid, 4-hydroxy-3,5-dimethoxy-, methyl ester
Formula	C10 H12 O5
CAS Number	884-35-5
FDA UNII	W5A196MP8A
Nikkaji Number	J356.639K
MDL	MFCD00017199
NMR Predictor	External link
Applications	natural substances and extractives
Synonyms	benzoic acid, 4-hydroxy-3,5-dimethoxy-, methyl ester methyl 4-hydroxy-3,5-dimethoxybenzoate methyl syringoate syringic acid methyl ester syringic acid monomethyl ester Syringic acid, methyl ester Methyl 3,5-dimethoxy-4-hydroxybenzoate 4-Hydroxy-3,5-dimethoxybenzoic acid methyl ester NSC 16946 NSC 611398 DeniLite II Assist Novoprime F 258 3,5-Dimethoxy-4-hydroxybenzoic acid methyl ester

Potential Uses

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	methyl 4-hydroxy-3,5-dimethoxybenzoate
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	70164
Pubchem (sid):	135027116
Pherobase:	View

Publications by PubMed
Immunochemical authentication of manuka honey using a monoclonal antibody specific to a glycoside of methyl syringate.
Plausible authentication of manuka honey and related products by measuring leptosperin with methyl syringate.
Differentiation of manuka honey from kanuka honey and from jelly bush honey using HS-SPME-GC/MS and UHPLC-PDA-MS/MS.
Pretreatment with laccase and a phenolic mediator degrades lignin and enhances saccharification of Eucalyptus feedstock.
Phytochemical and physical-chemical analysis of Polish willow (Salix spp.) honey: identification of the marker compounds.
The volatile profiles of a rare apple (Malus domestica Borkh.) honey: shikimic acid-pathway derivatives, terpenes, and others.
Cornflower (Centaurea cyanus L.) honey quality parameters: chromatographic fingerprints, chemical biomarkers, antioxidant capacity and others.
The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying.
Bioorganic diversity of rare Coriandrum sativum L. honey: unusual chromatographic profiles containing derivatives of linalool/oxygenated methoxybenzene.
Understanding pulp delignification by laccase-mediator systems through isolation and characterization of lignin-carbohydrate complexes.
Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1.
Obtaining biobleached eucalyptus cellulose fibres by using various enzyme combinations.
Methyl syringate: an efficient phenolic mediator for bacterial and fungal laccases.
Riboflavin and lumichrome in Dalmatian sage honey and other unifloral honeys determined by LC-DAD technique.
Laccase for biobleaching of eucalypt kraft pulp by means of a modified industrial bleaching sequence.
Polyphenolic profile as a useful tool to identify the wood used in wine aging.
Classification and characterization of manuka honeys based on phenolic compounds and methylglyoxal.
Identification of a novel glycoside, leptosin, as a chemical marker of manuka honey.
Isolation of methyl syringate as a specific aflatoxin production inhibitor from the essential oil of Betula alba and aflatoxin production inhibitory activities of its related compounds.
Towards industrially-feasible delignification and pitch removal by treating paper pulp with Myceliophthora thermophila laccase and a phenolic mediator.
Volatile compounds of Asphodelus microcarpus Salzm. et Viv. Honey obtained by HS-SPME and USE analyzed by GC/MS.
Phenolic compounds as enhancers in enzymatic and electrochemical oxidation of veratryl alcohol and lignins.
Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.
Composition of sulla (Hedysarum coronarium L.) honey solvent extractives determined by GC/MS: norisoprenoids and other volatile organic compounds.
Organic extractives from Mentha spp. honey and the bee-stomach: methyl syringate, vomifoliol, terpenediol I, hotrienol and other compounds.
Phenolic compounds in cherry ( Prunus avium ) heartwood with a view to their use in cooperage.
Biodegradability of kraft mill TCF biobleaching effluents: application of enzymatic laccase-mediator system.
Headspace, volatile and semi-volatile organic compounds diversity and radical scavenging activity of ultrasonic solvent extracts from Amorpha fruticosa honey samples.
Methyl syringate: a chemical marker of asphodel (Asphodelus microcarpus Salzm. et Viv.) monofloral honey.
Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants.
Mediator-assisted laccase-catalyzed oxidation of 4-hydroxybiphenyl.
Laccase-catalysed iodide oxidation in presence of methyl syringate.
Molecular determinants of substrate specificity in the feruloyl esterase module of xylanase 10B from Clostridium thermocellum.
Aromatic compound glucosides, alkyl glucoside and glucide from the fruit of anise.
Dioxygen reactivity of laccase: dependence on laccase source, pH, and anion inhibition.
Multichannel coulometric detection coupled with liquid chromatography for determination of phenolic esters in honey.
Synergistic action of phenolic signal compounds and carbohydrates in the induction of virulence gene expression of Agrobacterium tumefaciens.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Metabolomics Database:	Search
HMDB (The Human Metabolome Database):	Search
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View

Suppliers

BOC Sciences	Coompo
Sigma-Aldrich: Aldrich

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	212.20164489746
Flash Point TCC Value	132.4 °C TCC
logP (o/w)	1.1 est
Solubility
water, 1485 mg/L @ 25 °C (est)	Yes

Safety Information

Safety information

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
natural substances and extractives
Recommendation for methyl syringate usage levels up to:
	not for fragrance use.

Recommendation for methyl syringate flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :70164

National Institute of Allergy and Infectious Diseases:Data

methyl 4-hydroxy-3,5-dimethoxybenzoate

Chemidplus:0000884355