2-ethyl thiopyridine

2-ethyl thiopyridine is a heterocyclic organic compound characterized by a pyridine ring substituted at the 2-position with an ethylthio group. It appears as a liquid with notable organoleptic properties described as green, acid, cereal, bitter, and sour flavors. Synonyms include 2-ethylsulfanylpyridine and pyridine, 2-(ethylthio)-. This compound is part of a broader class of sulfur-containing pyridine derivatives. Its molecular formula is C₇H₉NS, and it has a molecular weight of 139.22 g/mol. Sourcing is primarily through chemical synthesis for research and reference purposes, and it is listed in controlled vocabularies such as PubChem where it is linked under CID 412543.

Biologically, 2-ethyl thiopyridine is not commonly found in natural sources but is synthesized for specialized research applications. Its sensory characteristics, including green and acid notes, suggest potential interest within flavor chemistry, though it is not used commercially in fragrances or flavors. Regulatory standards, for instance FEMA (US), reflect its classification primarily for informational purposes without approval for flavor or fragrance use. Its application is therefore limited to experimental contexts or as a chemical reference standard rather than in consumer products.

This compound exhibits a boiling point range from 228 to 229°C at atmospheric pressure and a reduced boiling point of approximately 77 to 77.5°C at 8 mmHg, indicating moderate volatility under vacuum. It has a flash point estimated at 197°F (about 92°C), which informs handling precautions. The estimated logP of 2.219 signifies moderate hydrophobicity, supporting solubility in alcohols but low solubility in water, with an estimated aqueous solubility around 828 mg/L at 25°C. A vapor pressure of 0.112 mmHg at 25°C suggests limited volatility at room temperature. These properties suggest that formulation considerations must address its moderate volatility and solvent compatibility, especially favoring organic solvents over aqueous media.

	2-ethylsulfanylpyridine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	412543
Pubchem (sid):	10411978

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 2-ethyl thiopyridine usage levels up to:
	not for fragrance use.
Recommendation for 2-ethyl thiopyridine flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :412543

National Institute of Allergy and Infectious Diseases:Data

2-ethylsulfanylpyridine