2-ethoxybenzene thiol

2-ethoxybenzene thiol, also known as 2-ethoxythiophenol, is an aromatic organosulfur compound characterized by the formula C₈H₁₀OS and a molecular weight of approximately 154.23 g/mol. It appears as a chemical entity noted for its rubbery flavor profile. This compound belongs to the benzenethiol chemical family with an ethoxy substitution positioned at the ortho location on the benzene ring. It can be referenced through standardized chemical databases like PubChem. Typically sourced via chemical synthesis in research settings, 2-ethoxybenzene thiol is primarily an informational compound with no assigned use in commercial flavor or fragrance preparations. Its organosulfur nature contributes to distinctive sensory characteristics and physicochemical behaviors notable in chemical studies.

2-ethoxybenzene thiol is not known to occur naturally in biological systems but is of interest in chemical research involving aromatic sulfur compounds. The compound is investigated for its physicochemical properties and sensory attributes, including its rubbery flavor note. It is primarily utilized as an informational reference in chemical and toxicological studies rather than in formulations for fragrances or flavorings. Regulatory guidelines such as those from FEMA (US) specify that this substance is not recommended for such applications. Its role in scientific contexts includes understanding organosulfur chemistry and potential synthesis intermediates. This information supports chemical safety evaluation and hazard identification in industrial or academic environments.

The physicochemical profile of 2-ethoxybenzene thiol plays a key role in its practical handling and potential application assessments. It exhibits a boiling point range from 234 to 235 °C at standard atmospheric pressure, indicating moderate volatility. The flash point is approximately 96 °C, reflecting its flammability threshold. At 25 °C, it has a vapor pressure of about 0.081 mmHg, signifying low volatility compared to more volatile organics. The estimated logP value near 2.83 suggests moderate lipophilicity, which impacts solubility characteristics. It is soluble in alcohol and shows limited water solubility, around 120.1 mg/L estimated at 25 °C. These properties influence its behavior in chemical formulations and environmental presence. The compound requires standard precautions during use and storage due to these physical parameters.

	2-ethoxybenzenethiol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	12772783
Pubchem (cas):	54615-63-3

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View

Safety information

Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
information only not used for fragrances or flavors
Recommendation for 2-ethoxybenzene thiol usage levels up to:
	not for fragrance use.
Recommendation for 2-ethoxybenzene thiol flavor usage levels up to:
	not for flavor use.

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :12772783

National Institute of Allergy and Infectious Diseases:Data

2-ethoxybenzenethiol