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sulfurol

Chemical Structure

General Material Information

Preferred name sulfurol
Trivial Name 4-Methyl-5-(2-hydroxyethyl)thiazole
Short Description 4-methyl-5-thiazoleethanol
Formula C6 H9 N O S
CAS Number 137-00-8
FEMA Number 3204
Flavis Number 15.014
ECHA Number 205-272-6
FDA UNII 3XYV4I47I8
Nikkaji Number J5.626J
Beilstein Number 0114249
MDL MFCD00005339
COE Number 11621
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1031 4-methyl-5-thiazoleethanol
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 137-00-8 ; 4-METHYL-5-THIAZOLEETHANOL
Synonyms
  • hemineurine
  • 5-hydroxyethyl-4-methyl thiazole
  • 5,2-hydroxyethyl-4-methyl thiazole
  • 5-hydroxyethyl-4-methylthiazole
  • 5-(2-hydroxyethyl)-4-methyl thiazole
  • 5-(beta- hydroxyethyl)-4-methyl thiazole
  • 5-(2-hydroxyethyl)-4-methylthiazole
  • 2-(4-methyl thiazol-5-yl) ethanol
  • methyl thiazolyl ethanol
  • 2-(4-methyl-1,3-thiazol-5-yl)ethanol
  • 4-methyl-5-(2-hydroxyethyl) thiazole
  • 4-methyl-5-(2-hydroxyethyl)-thiazole
  • 4-methyl-5-(2'-hydroxyethyl)-thiazole
  • 4-methyl-5-beta-hydroxyethyl thiazole
  • 4-methyl-5-hydroxethyl thiazole
  • 4-methyl-5-hydroxy ethyl thiazole
  • 4-methyl-5-thiazole ethanol
  • 4-methyl-5-thiazoleethanol
  • 4-methyl-5-thiazoleethanol (extra)
  • 4-methyl-5-thiazolyl ethanol
  • 4-methyl-5-thiazolylethanol
  • 2-(4-methylthiazol-5-yl)ethanol
  • 4-methylthiazol-5ylethanol
  • 2-(4-methylthiazole-5-yl)ethanol
  • quesote
  • quesote 10% ETOH natural
  • quesote 10% in TEC natural
  • sulfulin
  • sulfurol (4 methyl 5 thiazolethanol) (bean odor)
  • sulfurol (4 methyl 5 thiazolethanol) (fruity odor)
  • sulfurol (4 methyl 5 thiazolethanol) (meat odor)
  • sulfurol AP
  • sulfurol meaty
  • sulfurol milky
  • sulfurol RD
  • sulfurol SD
  • thiazole, 4-methyl-5-(2-hydroxyethyl)-
  • thiazole, 4-methyl-5-hydroxyethyl-
  • thiazole, 5-(2-hydroxyethyl)-4-methyl-
  • 5-thiazoleethanol, 4-methyl-
  • 2-(4-methyl-1,3-thiazol-5-yl)ethanol
  • 5-Thiazoleethanol, 4-methyl-
  • 4-Methyl-5-thiazoleethanol
  • 5-(2-Hydroxyethyl)-4-methylthiazole
  • 4-Methyl-5-(β-hydroxyethyl)thiazole
  • 4-Methyl-5-(2-hydroxyethyl)thiazole
  • MHT
  • 5-(Hydroxyethyl)-4-methylthiazole
  • 2-(4-Methylthiazole-5-yl)ethanol
  • 5-(β-Hydroxyethyl)-4-methylthiazole
  • 2-(4-Methyl-5-thiazolyl)ethanol
  • 4-Methyl-5-thiazolylethanol
  • NSC 23262
  • NSC 41831
  • 4-Methyl-5-(2-thiazoleethanol)
  • 2-(4-Methyl-1,3-thiazol-5-yl)ethan-1-ol

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Perfumer & Flavorists Start search
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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C04294
HMDB (The Human Metabolome Database):HMDB32985
FooDB:FDB010974
YMDB (Yeast Metabolome Database):YMDB00706
Export Tariff Code:2934.10.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

Suppliers

Advanced Biotech Ambles Nature et Chimie
Anhui Haibei Anhui Suzhou Jinli Aromatic Chemicals
Apple Flavor & Fragrance Augustus Oils
Beijing Lys Chemicals Berjé
BeYonde BOC Sciences
Charkit Chemical Citrus and Allied Essences
CJ Latta & Associates De Monchy Aromatics
DeLong Chemicals America Ernesto Ventós
Excellentia International FCI SAS
Fleurchem Frutarom
Fuzhou Farwell Glentham Life Sciences
IFF Indenta Group
Indukern F&F Jiangyin Healthway
Jinan Enlighten Chemical Technology(Wutong Aroma ) Kingchem Laboratories
Lluch Essence M&U International
Moellhausen O'Laughlin Industries
Omega Ingredients OQEMA
Pell Wall Perfumes Penta International
Primechem Prodasynth
Quimdis R C Treatt & Co Ltd
Reincke & Fichtner Riverside Aromatics
Santa Cruz Biotechnology Shanghai Vigen Fine Chemical
Sigma-Aldrich Soda Aromatic
SRS Aromatics Sunaux International
Synerzine Taytonn ASCC
TCI AMERICA Tengzhou Jitian Aroma Chemiclal
Tengzhou Xiang Yuan Aroma Chemicals The Lermond Company
Tianjin Danjun International United International
Vigon International WholeChem
Advanced Biotech. Inc. Augustus Oils Ltd
Beijing Lys Chemicals Co, LTD. Berje Inc.
Charkit Chemical Corporation CJ Latta & Associates, LLC
Fleurchem, Inc. Glentham Life Sciences Ltd
FRUTAROM USA INC, Indukern, S.A. F&F Ingredients Division
Jiangyin Healthway International Trade Co., Ltd Lluch Essence S.L.
M&U International LLC Moellhausen S.P.A.
O'Laughlin Industries Inc. Penta International Corporation
Anhui Primechem Co., Ltd. Riverside Aromatics Ltd.
Soda Aromatic Co., Ltd. SRS Aromatics Ltd
Synerzine, Inc. Taytonn ASCC Pte Ltd
Tianjin Danjun International Trade Co., LTD. R C Treatt and Co Ltd
Qingdao Free Trade Zone United International Co Ltd Ernesto Ventós S.A.
WholeChem, LLC

PhysChem Properties

Material listed in food chemical codex Yes
Molecular weight 143.20892333984
Specific gravity @ 25 °C
Pounds per Gallon 9.919 to 10.068
Refractive Index 1.548 to 1.552 @ 20 °C
Boiling Point 279 to 281°C @ 760 mm Hg
Vapor Pressure 0.003 mmHg @ 25 °C
Vapor Density 4.9
Flash Point TCC Value 110 °C TCC
logP (o/w) 0.275 est
Solubility
alcohol Yes
water Yes
water, 9081 mg/L @ 25 °C (est) Yes

Organoleptic Properties

Odor Type: Meaty
fatty, cooked, beef juice, meaty, brothy, nutty, yeasty, bready, oily, sulfurous
Luebke, William tgsc, (1997) At 100.00 %. fatty cooked beef juice
Mosciano, Gerard P&F 18, No. 4, 51, (1993) Meaty, brothy, nutty, yeasty and bready with an oily sulfureous nuance
Flavor Type: Meaty
meaty, brothy, roasted, metallic, nutty
Mosciano, Gerard P&F 18, No. 4, 51, (1993) At 20.00 ppm. Meaty, brothy, roasted, metallic and nutty
General comment Nutty; meaty, brothy, roasted, metallic

Occurrences

Potential Uses

Applications
Flavoring purposes Bacon, Bread, Cheese, Chocolate cocoa, Cognac, Egg, Meat, Milk, Nut, Peanut, Spearmint, Yeast
Cosmetic purposes Perfuming agents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 [sex: M,F] 4800 mg/kg
(Calvary & Nelson, 1944)

oral-rat LD50 2450 mg/kg
(Calvary & Nelson, 1944)

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for sulfurol usage levels up to:
0.0200 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 150.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 380.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
average usual ppmaverage maximum ppm
baked goods: -55.00000
beverages(nonalcoholic): -55.00000
beverages(alcoholic): --
breakfast cereal: -55.00000
cheese: --
chewing gum: -55.00000
condiments / relishes: -55.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -55.00000
fruit ices: -55.00000
gelatins / puddings: -55.00000
granulated sugar: --
gravies: -55.00000
hard candy: -55.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -55.00000
milk products: -55.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -55.00000
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf

Scientific Opinion on the safety and efficacy of thiazoles, thiophene, thiazoline and thienyl derivatives (chemical group 29): 3-acetyl-2,5-dimethylthiophene when used as a flavouring for all animal species
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf

Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):137-00-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1136
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(4-methyl-1,3-thiazol-5-yl)ethanol
Chemidplus:0000137008