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tetrahydrofurfuryl acetate

Chemical Structure

General Material Information

Preferred name tetrahydrofurfuryl acetate
Trivial Name Tetrahydrofurfuryl acetate
Short Description tetrahydro-2-furanylmethyl acetate
Formula C7 H12 O3
CAS Number 637-64-9
Deleted CAS Number 52630-61-2
FEMA Number 3055
Flavis Number 13.166
ECHA Number 211-296-8
FDA UNII I1PIW4REZU
Nikkaji Number J101.366A
MDL MFCD00022478
COE Number 2069
xLogP3-AA 0.50 (est)
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 1442 tetrahydrofurfuryl acetate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 637-64-9 ; TETRAHYDROFURFURYL ACETATE
Synonyms
  • 2-acetoxymethyl oxolane
  • 2-( acetoxymethyl) tetrahydrofuran
  • 2-( acetoxymethyl)oxolane
  • acetoxymethyl)tetrahydrofuran
  • 2-( acetoxymethyl)tetrahydrofuran
  • 2-furanmethanol, tetrahydro-, acetate
  • furfuryl alcohol, tetrahydro-, acetate
  • oxolan-2-ylmethyl acetate
  • tetrahydro furfuryl acetate
  • tetrahydro-2-furan methanol acetate
  • tetrahydro-2-furanmethanol acetate
  • tetrahydro-2-furanylmethyl acetate
  • tetrahydro-2-furyl methyl acetate
  • tetrahydro-2-furylmethyl acetate
  • tetrahydrofuran-2-ylmethyl acetate
  • tetrahydrofurfuryl acetate natural
  • tetrahydrofurfurylacetate
  • 2-Furanmethanol, tetrahydro-, 2-acetate
  • 2-Furanmethanol, tetrahydro-, acetate
  • 2-(Acetoxymethyl)oxolane
  • 2-(Acetoxymethyl)tetrahydrofuran
  • NSC 4872
  • (Tetrahydrofuran-2-yl)methyl acetate
  • (Oxolan-2-yl)methyl acetate

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB31176
FooDB:FDB003195
Export Tariff Code:2933.19.4300
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 144.17024230957
Specific gravity @ 25 °C
Pounds per Gallon 8.804 to 8.854
Refractive Index 1.435 to 1.44 @ 20 °C
Boiling Point 194 to 195°C @ 753 mm Hg
Acid Value 4 max KOH/g
Vapor Pressure 0.249 mmHg @ 25 °C
Vapor Density 4.9
Flash Point TCC Value 68.33 °C TCC
logP (o/w) 0.349 est
Solubility
alcohol Yes
chloroform Yes
ethyl ether Yes
water, 1.384e+004 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Fruity
fruity, ethereal, rummy, brown, cooked, cognac, tequila, caramellic, nutty, sweet
Odor strength medium
Substantivity 3 hour(s) at 100.00 %
Luebke, William tgsc, (2021) At 100.00 %. fruity ethereal rummy caramel brown cooked cognac tequila caramellic nutty
Mosciano, Gerard P&F 19, No. 2, 55, (1994) Sweet, fruity, brown, rummy, slightly etherial with caramel nuance
Flavor Type: Brown
brown, ethereal, rummy, nutty, nut skin, tequila, bready, caramellic, sweet
Luebke, William tgsc, (2021) Brown ethereal rummy nutty nut skin tequila bready caramellic
Mosciano, Gerard P&F 19, No. 2, 55, (1994) At 100.00 ppm. Sweet, brown, caramel-like with nutty rummy nuances
General comment Sweet brown caramel nut rum

Potential Uses

Applications
Odor purposes Apricot, Butterscotch, Coffee, Fruit, Honey, Maple, Saffron
Flavoring purposes Bread, Caramel, Grain, Nut
Cosmetic purposes Fragrance, Solvents

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for tetrahydrofurfuryl acetate usage levels up to:
4.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.60 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 8.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
average usual ppmaverage maximum ppm
baked goods: 1.0000020.00000
beverages(nonalcoholic): 1.300002.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -8.00000
fruit ices: -8.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 1.0000020.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 75 (FGE.75)[1] - Consideration of tetrahydrofuran derivatives and a furanone derivative evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 75, Revision 1 (FGE.75Rev1): Consideration of tetrahydrofuran derivatives evaluated by JECFA (63rd meeting) structurally related to tetrahydrofuran derivatives evaluated by EFSA in FGE.33 (2008)
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):637-64-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :12506
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
oxolan-2-ylmethyl acetate
Chemidplus:0000637649