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phenyl acetate

Chemical Structure

General Material Information

Preferred name phenyl acetate
Trivial Name Phenyl acetate
Short Description acetic acid, phenyl ester
Formula C8 H8 O2
CAS Number 122-79-2
FEMA Number 3958
Flavis Number 9.688
ECHA Number 204-575-0
FDA UNII 355G9R500Y
Nikkaji Number J32.787E
Beilstein Number 0636458
MDL MFCD00008699
COE Number 10878
Bio Activity Summary External link
NMR Predictor External link
JECFA Food Flavoring 734 phenyl acetate
FDA Patent No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm 122-79-2 ; PHENYL ACETATE
Synonyms
  • acetic acid phenyl ester
  • acetic acid, phenyl ester
  • acetoxybenzene
  • ( acetyl oxy) benzene
  • acetyl phenol
  • phenylacetate
  • Phenol acetate
  • (Acetyloxy)benzene
  • NSC 27795
  • 2-Acetoxybenzene

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Literature & References

phenyl acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:122-79-2
Pubchem (cid):31229
Pubchem (sid):134974053
Pherobase:View
Publications by PubMed
New Chemiluminescent Substrates of Paraoxonase 1 with Improved Specificity: Synthesis and Properties.
In vitro evaluation of 3-arylcoumarin derivatives in A549 cell line.
DFT electronic structure calculations, spectroscopic studies, and normal coordinate analysis of 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate.
Phenyl acetate derivatives, fluorine-substituted on the phenyl group, as rapid recovery hypnotic agents with reflex depression.
Bioactive Metabolites Produced by Pseudonocardia endophytica VUK-10 from Mangrove Sediments: Isolation, Chemical Structure determination and Bioactivity.
Westerdijkin A, a new hydroxyphenylacetic acid derivative from deep sea fungus Aspergillus westerdijkiae SCSIO 05233.
Profile of volatile components of hydrodistilled and extracted leaves of Jacaranda acutifolia and their antimicrobial activity against foodborne pathogens.
Exploring the aryl esterase catalysis of paraoxonase-1 through solvent kinetic isotope effects and phosphonate-based isosteric analogues of the tetrahedral reaction intermediate.
[Study on the safety and efficacy of sitafloxacin at a dose of 100 mg once a day--results of the use-results survey].
Paraoxonase 1 polymorphisms within a Mississippi USA population as possible biomarkers of enzyme activities associated with disease susceptibility.
Study on the synthesis of sulfonamide derivatives and their interaction with bovine serum albumin.
Purification and characterization of paraoxonase 1 (PON1) from Swiss Black, Holstein, and Montofon bovines.
2-(5-Methyl-1,3,4-oxa-diazol-2-yl)phenyl acetate.
Characterization of a versatile arylesterase from Lactobacillus plantarum active on wine esters.
Improving the catalytic properties of immobilized Lecitase via physical coating with ionic polymers.
Synthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agents.
Prognostic value of paraoxonase 1 in patients undergoing coronary artery bypass grafting surgery.
Autonomic healing of carbon fiber/epoxy interfaces.
2-Isopropyl-4-meth-oxy-5-methyl-phenyl acetate.
Tetra-kis(μ-2-phenyl-acetato-κ(2) O:O')bis-{[4-(di-methyl-amino)-pyridine-κN (1)]cobalt(II)}.
Room temperature self-healing thermoset based on the Diels-Alder reaction.
Correlation between Cholinesterase and Paraoxonase 1 Activities:Case Series of Pesticide Poisoning Subjects.
4-{(E)-[2-(Pyridin-3-ylcarbon-yl)hydrazinyl-idene]meth-yl}phenyl acetate.
Temperature dependence of binding and catalysis for human serum arylesterase/paraoxonase.
catena-Poly[bis-(μ3-2-phenyl-acetato-κ(3) O,O':O)bis-(μ2-2-phenyl-acetato-κ(2) O:O')dicopper(II)(Cu-Cu)].
Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients.
The determination of Q192R polymorphism of paraoxonase 1 by using non-toxic substrate p-nitrophenylacetate.
Validating a breath collection and analysis system for the new tuberculosis breath test.
2-[3-(2-Acetoxyphenyl)quinoxa-lin-2-yl]phenyl acetate.
Paraoxonase (PON)-1 activity in overweight and obese children and adolescents: association with obesity-related inflammation and oxidative stress.
Vibrational spectroscopic investigations and computational study of 5-chloro-2-[4-(trifluoromethyl)phenylcarbamoyl]phenyl acetate.
Effect of insulin analog initiation therapy on LDL/HDL subfraction profile and HDL associated enzymes in type 2 diabetic patients.
Small high-density lipoprotein (HDL) subclasses are increased with decreased activity of HDL-associated phospholipase A₂ in subjects with prediabetes.
Synthesis of some new thioxoquinazolinone derivatives and a study on their anticonvulsant and antimicrobial activities.
Immobilization of tyrosinase on modified diatom biosilica: enzymatic removal of phenolic compounds from aqueous solution.
Interorgan metabolism of ornithine phenylacetate (OP)--a novel strategy for treatment of hyperammonemia.
Stereochemically probing the photo-Favorskii rearrangement: a mechanistic investigation.
Molecular characterization of a novel arylesterase from the wine-associated acetic acid bacterium Gluconobacter oxidans 621H.
Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
4-{[8-(4-Acetyl-oxybenzo-yl)-2,7-dimeth-oxy-naphthalen-1-yl]carbon-yl}phenyl acetate.
Paraoxonase 1 activity in multiple sclerosis patients during mitoxantrone therapy.
Salt overload in fructose-fed insulin-resistant rats decreases paraoxonase-1 activity.
Impact of trace element addition on degradation efficiency of volatile fatty acids, oleic acid and phenyl acetate and on microbial populations in a biogas digester.
Novel associations of nonstructural Loci with paraoxonase activity.
Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease.
Penicillin production by wild isolates of Penicillium chrysogenum in Pakistan.
Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association.
4-[(E)-(3-Chloro-4-methyl-phen-yl)imino-meth-yl]-2-methoxy-3-nitro-phenyl acetate.
Evaluation of a new substrate for measurement of serum PON arylesterase activity.
2-Cyano-N'-[1-(2-hy-droxy-phen-yl)ethyl-idene]acetohydrazide monohydrate.
Validation of spectrophotometric assays for serum paraoxonase type-1 measurement in dogs.
{4-Dimethyl-amino-N'-[1-(2-oxidophen-yl)ethyl-idene]benzohydrazidato}(methano-lato)oxidovanadium(V).
Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.
Bis(μ-2-phenyl-acetato-κO:O)bis-[(2,2'-bipyridyl-κN,N')(2-phenyl-acetato-κO)copper(II)] dihydrate.
A new family of carbohydrate esterases is represented by a GDSL hydrolase/acetylxylan esterase from Geobacillus stearothermophilus.
Relationship of human paraoxonase-1 serum activity and genotype with atherosclerosis in individuals from the Deep South.
Effect of dilution on high-density lipoprotein associated paraoxonase-1 activity.
(2-Acetyl-phenolato)(2-{1-[2-(morpholin-4-yl)ethyl-imino]-eth-yl}phenolato)(thio-cyanato-κN)-cobalt(III).
(E)-4-{[2-(2-Furylcarbon-yl)hydrazinyl-idene]meth-yl}-2-meth-oxy-phenyl acetate.
Cytotoxic activity of new acetoxycoumarin derivatives in cancer cell lines.
Antistaphylococcal activity of novel salicylanilide derivatives.
Molecular cloning and characterization of a novel SGNH arylesterase from the goat rumen contents.
[μ-2-(4-Hy-droxy-phen-yl)acetato]-κO:O,O';κO,O':O'-bis-{aqua-(4,4'-bi-pyridine-κN)bis-[2-(4-hy-droxy-phen-yl)acetato-κO,O']holmium(III)} mono-hydrate.
Studies on the chemical constituents of Anabasis aphylla L.
[¹¹C]diclofenac sodium: synthesis and PET assessment of transdermal penetration.
Two new resorcinol derivatives with strong cytotoxicity from the roots of Ardisia brevicaulis Diels.
Differential hydrolysis of homocysteine thiolactone by purified human serum (192)Q and (192)R PON1 isoenzymes.
New Cu(II) complexes based on the hydroxo-bridged dinuclear [Cu(OH)2Cu] units: step-like di- and trimerizations of [Cu(OH)2Cu] units.
Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
A reverse phase HPLC method for the separation of two stereo isomers of 2-[4-(methylsulfonyl)phenyl]-3-(3(R)-oxocyclopentyl)propanoic acid.
Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage.
Synthesis and characterization of polycarbonates by melt phase interchange reactions of alkylene and arylene diacetates with alkylene and arylene diphenyl dicarbonates.
The differentiating effect of glimepiride and glibenclamide on paraoxonase 1 and platelet-activating factor acetylohydrolase activity.
Purification and kinetic properties of rabbit liver paraoxonase 1.
Development of chemical probes: toward the mode of action of a methylene-linked di(aryl acetate) E1.
Synthesis of 4',7-diacetoxyapigenin and its apoptotic induction in human Hep G2 cells.
Oral bioavailability, efficacy and gastric tolerability of P2026, a novel nitric oxide-releasing diclofenac in rat.
A unique pharmacophore for activation of the nuclear orphan receptor Nur77 in vivo and in vitro.
Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.
Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae.
Structural basis for inverting the enantioselectivity of arylmalonate decarboxylase revealed by the structural analysis of the Gly74Cys/Cys188Ser mutant in the liganded form.
4-Carbamoylpiperidinium phenyl-acetate hemihydrate.
3-Ethyl 2-methyl 8-bromo-2-phenyl-1,2,3,3a,4,9b-hexa-hydro-chromeno[4,3-b]pyrrole-2,3-dicarboxyl-ate.
Tetra-kis[μ-2-(4-hy-droxy-phenyl)-acetato]-κO,O':O;κO:O,O'-bis-{aqua-(4,4'-bi-pyridine-κN)bis-[2-(4-hy-droxy-phenyl)-acetato-κO,O]neodymium(III)} monohydrate.
Guanidinium 2-phenyl-acetate.
catena-Poly[[[(2-phenyl-acetato-κO)zinc(II)]bis-[μ-4,4'-(disulfanedi-yl)dipyridine-κN:N']] monohydrate].
Dihydro-myricetin hexa-acetate.
Tetra-kis(μ-3,4-dimeth-oxy-phenyl-acetato)-bis-[(3,4-dimeth-oxy-phenyl-acetato)(1,10-phenanthroline)holmium(III)].
2-[4-Acetyl-5-(biphenyl-4-yl)-4,5-dihydro-1,3,4-oxadiazol-2-yl]phenyl acetate.
catena-Poly[[[aqua-[(2-hydroxy-phen-yl)acetato-κO,O']lead(II)]-μ(3)-[(2-hydroxy-phen-yl)acetato-κO:O,O':O']] monohydrate].
4-{[(4Z)-5-Oxo-2-phenyl-4,5-dihydro-1,3-oxazol-4-yl-idene]meth-yl}phenyl acetate.
Octa-kis(2-chloro-benz-yl)di-μ(2)-hydroxido-di-μ(3)-oxido-bis-(2-phenyl-acetato)tetra-tin(IV).
3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate induced Hep G2 cell apoptosis through a ROS-mediated pathway.
High molecular-weight gelatinase species of human Bruch's membrane: compositional analyses and age-related changes.
Synthesis of cholesterol-conjugated magnetic nanoparticles for purification of human paraoxonase 1.
High prevalence of low serum paraoxonase-1 in subjects with coronary artery disease.
Solvation of dichlorocarbene: complexation with aryl ethers.
Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes.
Racial differences in paraoxonase-1 (PON1): a factor in the health of southerners?
The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells.
Acetoxybenzhydrols as highly active and stable analogues of 1'S-1'-acetoxychavicol, a potent antiallergic principal from Alpinia galanga.
Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution.
Total synthesis of psoralidin, an anticancer natural product.
FT-IR, FT-Raman and DFT calculations of 4-chloro-2-(3,4-dichlorophenylcarbamoyl)phenyl acetate.
2-[3-Acetyl-5-(2-chloro-3-pyrid-yl)-2-methyl-2,3-dihydro-1,3,4-oxadiazol-2-yl]-4-fluoro-phenyl acetate.
4-Acetamido-3-nitro-phenyl acetate.
3-[(E)-2-(5,7-Dichloro-8-hydroxy-quinolin-2-yl)vin-yl]-4-hydroxy-phenyl acetate.
Tetra-kis(μ(2)-3,4-dimethoxy-phenyl-acetato)-κO,O':O';κO:O:O';κO:O';κO:O'-bis-[(3,4-dimethoxy-phenyl-acetato-κO,O')(1,10-phenanthroline-κN,N)thulium(III)].
A cycloaddition product of a chiral maleimide: 4-{(3aS*,6aS*)-4,6-dioxo-1-phenyl-5-[(1R)-1-phenyl-ethyl]-1,3a,4,5,6,6a-hexa-hydro-pyrrolo[3,4-c]pyrazol-3-yl}phenyl acetate.
Tetra-kis(μ(2)-phenyl-acetato-κO:O')bis-[(isoquinoline-κN)copper(II)].
Trimethyl 5-(2-chloro-4-fluoro-phen-yl)-2-phenyl-pyrrolidine-2,3,4-tricarboxyl-ate.
4-[(2-Methyl-5-oxo-4,5-dihydro-1,3-oxazol-4-yl-idene)meth-yl]phenyl acetate.
Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases.
Determinants of variation in human serum paraoxonase activity.
A novel thermostable arylesterase from the archaeon Sulfolobus solfataricus P1: purification, characterization, and expression.
Paraoxonase 1 activity in different types of multiple sclerosis.
Inhibitory effect of some acetyl esters and acetamides on glycation of the histone H1.
Predicting reactivities of organic molecules. Theoretical and experimental studies on the aminolysis of phenyl acetates.
Localization and characterization of the novel protein encoded by C20orf3.
High plasma C-reactive protein (CRP) is related to low paraoxonase-I (PON-I) activity independently of high leptin and low adiponectin in type 2 diabetes mellitus.
3-Hydr-oxy-4-nitro-phenyl acetate.
Methyl 2-[2-(2,6-dichloro-anilino)-phenyl]-acetate.
Poly[potassium-μ-2-[2-(carboxymethyl)phenyl]acetato].
(S)-N-[(1S,2S)-2-Benzyl-amino-1-(4-hy-droxy-phen-yl)-3-methyl-butyl]-1,1-di-methyl-ethane-2-sulfinamide.
Bis(1,10-phenanthroline-κN,N')(phenyl-acetato-κO)copper(II) phenyl-acetate hexa-hydrate.
(E)-2-Meth-oxy-4-(3-oxobut-1-en-yl)phenyl acetate.
4-(7-Acet-oxy-6-meth-oxy-4-methyl-2-oxo-2H-chromen-3-yl)phenyl acetate.
(Z)-2-(2-Chloro-3,3,3-trifluoro-prop-1-en-yl)-6-methoxy-phenyl acetate.
Dimethyl 6H,12H-5,11-methano-dibenzo[b,f][1,5]diazo-cine-2,8-diacetate.
Ethyl 4-nitro-phenyl-acetate.
Two novel compounds from Ardisia punctata Lindl.
Increased glutathione levels and activity of PON1 (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide: a defense mechanism?
[14C]Benzyl acetate is a potential radiotracer for the measurement of glial metabolism in the rat brain.
WITHDRAWN: Increased glutathione levels and activity of PON(1) (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide; a defense mechanism?
Bioreversible derivatives of phenol. 2. Reactivity of carbonate esters with fatty acid-like structures towards hydrolysis in aqueous solutions.
Simple procedures for purification and stabilization of human serum paraoxonase-1.
Reduced paraoxonase1 activity is a risk for atherosclerosis in patients with systemic lupus erythematosus.
The distribution of esterases in the skin of the minipig.
Nanostructured biosensor for measuring neuropathy target esterase activity.
Ethyl 2-acetyl-hydrazono-2-phenyl-acetate.
Activity of paraoxonase 1 (PON1) and its relationship to markers of lipoprotein oxidation in healthy Slovaks.
Ab initio study of the substituent effects on the relative stability of the E and Z conformers of phenyl esters. Stereoelectronic effects on the reactivity of the carbonyl group.
Two isomeric butadiene-N-(acetoxyphenyl)maleimide Diels-Alder adducts: supramolecular structure directed by C-H...X (X = O and pi) hydrogen bonds and perpendicular dipole carbonyl-carbonyl interactions.
Serum arylesterase and paraoxonase activity in patients with chronic hepatitis.
Hybrid aza-steroid alkylators in the treatment of colon cancer.
Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer.
Lack of association between carotid intima-media thickness and PAF-acetylhydrolase mass and activity in patients with primary hyperlipidemia.
Iron-ascorbic acid-induced oxidant stress and its quenching by paraoxonase 1 in HDL and the liver: comparison between humans and rats.
Prediction of the wine sensory properties related to grape variety from dynamic-headspace gas chromatography-olfactometry data.
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.
Purification and characterization of carbonic anhydrase from bovine stomach and effects of some known inhibitors on enzyme activity.
Evaluation of a dedicated gas chromatography-mass spectrometry method for the analysis of phenols in water.
Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates.
Paraoxonase-1 (PON-1) genotype and activity and in vivo oxidized plasma low-density lipoprotein in Type II diabetes.
Differential effect of antioxidant treatment on plasma and tissue paraoxonase activity in hyperleptinemic rats.
Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia.
[Decrease of paraoxonase activity in the first day after abdominal operations in women].
Acetoclastic and hydrogenotrophic methane production and methanogenic populations in an acidic West-Siberian peat bog.
Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model.
Polyphenols from peanut skins and their free radical-scavenging effects.
Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids.
Structure of an aryl esterase from Pseudomonas fluorescens.
Exo Diels-Alder adducts between ortho- and para-N-acetoxyphenylmaleimides and furan.
Reactivity of molybdenum and rhenium hydroxo-carbonyl complexes toward organic electrophiles.
Synthesis of a spirocyclic indoline lactone.
The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192).
Molecular determinants of vanilloid sensitivity in TRPV1.
Effect of 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities.
Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia.
Differential effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on plasma paraoxonase 1 activity in the rat.
Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors.
A 1,2,4-diazaphospholane complex of rhodium.
Synthesis and antimalarial activity of some new 1,2-dioxolane derivatives.
Kinetic substrate quantification by fitting the enzyme reaction curve to the integrated Michaelis-Menten equation.
Inhibition of human serum arylesterase by metal chlorides.
Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration.
Europium ion catalyzed methanolysis of esters at neutral pH and ambient temperature. catalytic Involvement of Eu3+(CH3O-)(CH3OH)x.
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Fast, easy, and efficient method for the purification of phenolic isomers using a selective solid-phase scavenging process.
Observation of an arsenic adduct in an acetyl esterase crystal structure.
The effect of peroxisome proliferator-activated receptors alpha (PPARalpha) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity, and plasma paraoxonase 1 (PON 1) activity.
Detection of organophosphorus insecticides with immobilized acetylcholinesterase - comparative study of two enzyme sensors.
Semi-volatile organic compounds at the leaf/atmosphere interface: numerical simulation of dispersal and foliar uptake.
Cerivastatin modulates plasma paraoxonase/arylesterase activity and oxidant-antioxidant balance in the rat.
Heteropoly acid as a novel efficient catalyst for Fries rearrangement.
[The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus].
High-density lipoprotein composition and paraoxonase activity in Type I diabetes.
Assay of serum arylesterase activity by fitting to the reaction curve with an integrated rate equation.
Fidelity in Hapten Design: How Analogous Are Phosphonate Haptens to the Transition States for Alkaline Hydrolyses of Aryl Esters?
Dissection of Nucleophilic and General Base Roles for the Reaction of Phosphate with p-Nitrophenyl Thiolacetate, p-Nitrophenyl Thiolformate, and Phenyl Thiolacetate.
Anti-inflammatory drugs. X. Hydrated pyrrolidinium [2-[(2,6-dichlorophenyl)amino]phenyl]acetate(HP.D.H2O).
Aspirin. An ab initio quantum-mechanical study of conformational preferences and of neighboring group interactions.
Anti-inflammatory drugs. IX. Hydrated diethylammonium (2-(2,6-dichlorophenylamino)phenyl)acetate (HDEA.D.H2O).
Hydrolysis of platelet-activating factor by human serum paraoxonase.
Suppression of depleted uranium-induced neoplastic transformation of human cells by the phenyl fatty acid, phenyl acetate: chemoprevention by targeting the p21RAS protein pathway.
Conversion of 4-hydroxyacetophenone into 4-phenyl acetate by a flavin adenine dinucleotide-containing Baeyer-Villiger-type monooxygenase.
Aspirin esterases in North-West Indians: the influence of age and nutrition.
Properties of soluble alpha-chymotrypsin in neat glycerol and water.
Catalysis of acyl group transfer by a double-displacement mechanism: the cleavage of aryl esters catalyzed by calixcrown-Ba2+ complexes
Synthesis of mimosamycin.
[Microbial degradation of components of waste water from phenol-producing industry].
Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.
Paraoxonase (PON1) polymorphism & its relation with lipids in north west Indian Punjabis.
Fatal fulminant hepatitis associated with bromfenac use.
Paraoxonase polymorphism in rabbits.
Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate.
Purification and characterization of an esterase involved in poly(vinyl alcohol) degradation by Pseudomonas vesicularis PD.
In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT.
Decrease of serum paraoxonase activity in chronic renal failure.
Paraoxonase as a risk marker for cardiovascular disease: facts and hypotheses.
Purification of two rat hepatic proteins with A-esterase activity toward chlorpyrifos-oxon and paraoxon.
Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
Metabolism of 14C-moxisylyte after percutaneous application in hairless rat.
Effect of Cation-Complexing Agents on the Ba(II)-Assisted Basic Ethanolysis of Phenyl Acetate: From Cation Deactivation to Cation Activation.
Partial inactivation of chorismate mutase-prephenate dehydrogenase from Escherichia coli in the presence of analogues of chorismate.
The thioesterase I of Escherichia coli has arylesterase activity and shows stereospecificity for protease substrates.
Some cyclic nucleotides reduce phenylephrine-induced and phorbol ester-induced constriction of the rat anterior mesenteric artery.
Identification and isolation of two rat serum proteins with A-esterase activity toward paraoxon and chlorpyrifos-oxon.
Pharmacokinetics study of 14C-moxisylyte after percutaneous application to hairless rat.
New bioactive adjacent bis-THF annonaceous acetogenins from Annona bullata.
Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation.
Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase.
The application of stereolithography to the fabrication of accurate molecular models.
New insights on the specificity of penicillin acylase.
Metabolism of 14C-moxisylyte in hairless rat. Comparison between intravenous and oral route.
Anti-inflammatory drugs: 1-(2-hydroxyethyl)pyrrolidinium salt of diclofenac.
Mechanism-based catalytic antibody inactivation.
Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization.
Evaluation of kidney and liver subacute toxicity of antitumor agents using serum biochemical parameters in rats.
14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux.
A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate.
Rapid presumptive identification and further characterization of Bacteroides forsythus.
Anaerobic degradation of 3-hydroxybenzoate by a newly isolated nitrate-reducing bacterium.
Mechanistic studies of a tyrosine-dependent catalytic antibody.
[A potentiometric rapid method of determining the level of phenylacetic acid during the production of beta-lactam antibiotics].
[Wet oxidation of toxic industrial waste with oxygenated water].
Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis.
Noninvasive tracing of Krebs cycle metabolism in liver.
High paraoxon-hydrolyzing activity in organophosphorus insecticide-resistant mosquitoes.
[Separation and resolution of four stereo-isomers of anisodamine].
Potentiometric biosensor employing catalytic antibodies as the molecular recognition element.
Oxime-induced reactivation of acetylcholinesterase inhibited by organophosphinates.
Preparation and properties of (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl- (R)-(+)-alpha-hydroxy-alpha-(4-[125I]iodophenyl)-alpha-phenyl acetate and (R)-(-)-1-azabicyclo[2.2.2]oct-3-yl-(S)-(-)-alpha-hydroxy-alpha- (4-[125I]iodophenyl)-alpha-phenyl acetate as potential radiopharmaceuticals.
Spectrophotometric assays for the enzymatic hydrolysis of the active metabolites of chlorpyrifos and parathion by plasma paraoxonase/arylesterase.
Laboratory investigation of hospital outbreak caused by two different multiresistant Acinetobacter calcoaceticus subsp. anitratus strains.
Automated robotic extraction and subsequent analysis of diclofenac in plasma samples.
Monoclonal antibody NMS-1 increases N-formyl chemotactic peptide-mediated oxidative burst generation in human neutrophils.
Improved methodology for intracellular enzyme reaction and inhibition kinetics by flow cytometry.
Characteristics and sites of infection of Eubacterium nodatum, Eubacterium timidum, Eubacterium brachy, and other asaccharolytic eubacteria.
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
Semiochemical attractants ofDiabrotica undecimpunctata howardi barber, southern corn rootworm, andDiabrotica virgifera virgifera leconte, the western corn rootworm (Coleoptera: Chrysomelidae).
Carboxylesterases in the respiratory tracts of rabbits, rats and Syrian hamsters.
In vitro protein binding of diclofenac sodium in plasma and synovial fluid.
Investigations of primary and secondary structure of porcine ubiquitin. Its N epsilon-acetylated lysine derivative.
A biochemical explanation of phenyl acetate neurotoxicity in experimental phenylketonuria.
N-epsilon-acetylation of porcine mature erythrocytes ubiquitin.
[125I] 3-quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors.
Further studies on the anti-neoplastic activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstan-17-oic-13,17-lactam [p-[bis(2-chloroethyl)amino]-phenyl]acetate (NSC 290205).
Stimulation of h efflux and inhibition of photosynthesis by esters of carboxylic acids.
Trypsin inhibitor effects on food intake and weight gain in Zucker rats.
Urinary phenyl acetate: a diagnostic test for depression?
Recognition of lambda 1 and lambda 2 murine light chains by carrier-specific isologous T helper cells; effect of L-H chain assembly.
Changes of the Met-enkephalin-like peptide content induced by noxious stimuli in the rat incisor pulp.
1-Bromopinacolone, an active site-directed covalent inhibitor for acetylcholinesterase.
Interaction of specific amino acid derivatives with dimeric alpha-chymotrypsin.
Activity of 3 beta-hydroxy-13 alpha-amino-13,17-seco-5 alpha-androstane-17-oic-13,17-lactam(p-(bis(2-chloroethyl)amino)-phenyl) acetate(NSC 290205) in murine solid tumors.
Tubulinyl-tyrosine carboxypeptidase from chicken brain: properties and partial purification.
Arylesterase in serum: elaboration and clinical application of a fixed-incubation method.
Studies on acid lipase, and E 600-resistant acid esterase activities in human tissue homogenates.
Bioassay of Estradiol Mustard for Possible Carcinogenicity (CAS No. 22966-79-6).
Effects of cholinesterase inhibitors on the spasmogenic action of acetate esters on rat uterus.
Penetration of antibiotics into bile.
The mode of binding of potential transition-state analogs to acetylcholinesterase.
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition. II. Characterization of the reactivating components.
alpha-chymotrypsin-catalyzed hydrolysis of phenyl acetate. Large Hammett's rho constant and participation of histidine-acylated intermediate.
Aspects of the spasmogenic effects of acetate esters on ileal smooth muscle.
Mechanisms of acylation of chymotrypsin by phenyl esters of benzoic acid and acetic acid.
[On the efficiency of new antiinflammatory agents. A comparative study (author's transl)].
Quantitative determination of sodium-o-[(2,6-dichlorophenyl)-amino]phenylacetate (diclofenac) in human blood plasma or serum.
Indophenyl acetate and acetylcholinesterase: binding of a non-specific substrate on the margin of the active center.
Acylation of phenol by cyclic and acyclic anhydrides in anhydrous acetic acid.
The microbial metabolism of acetophenone. Metabolism of acetophenone and some chloroacetophenones by an Arthrobacter species.
Catalysis by acetylcholinesterase: evidence that the rate-limiting step for acylation with certain substrates precedes general acid-base catalysis.
[Chymotrypsin-like proteinases in microbial proteolytic complexes].
A steady-state kinetic model of butyrylcholinesterase from horse plasma.
Effects of lipid removal on the molecular size and kinetic properties of bovine plasma arylesterase.
Sodium (o-((2,6-dichlorophenyl)-amino)-phenyl)-acetate (GP 45 840), a new non-steroidal anti-inflammatory agent.
Release of phenyl acetate esterase from liver microsomes by carbon tetrachloride.
[Effect of calcium and magnesium ions, as a function of pH, on hydrolysis of phenyl acetate by erythrocyte esterases].
[Potentiating effects of choline on the action of phenyl acetate. 5. Effects of inhibitors of acetylcholine liberation].
[Kinetics of enzymatic hydrolysis of phenyl acetate].
Evaluation of phenyl acetate esterase activity as an index of liver damage.
Aminolysis of esters. VII. The reaction of lysine with phenyl acetate and triacetin.
[Application of phenyl acetate esterase activity determination in liver function tests].
Effects of strychnine, derivatives of phenyl acetate and catecholamines on contraction and acetylcholine output from the cholinergic nerve ending of guinea pig ileum.
Effects of phenyl acetate and its analogues on isolated guinea-pig small intestine.
Curtain electrophoretic separation of phenyl acetate hydrolysing esterases of human serum. Demonstration of an EDTA-dependent enzyme.
The effect of substituents on the hydrolysis of phenyl acetate by wheat germ lipase.
STUDIES ON ENZYME ACTION : XXXV. LIPASE ACTIONS OF EXTRACTS OF TISSUES OF RABBITS AT DIFFERENT AGES.

Other Information

(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C00548
HMDB (The Human Metabolome Database):HMDB40733
FooDB:FDB020542
YMDB (Yeast Metabolome Database):YMDB00838
Export Tariff Code:2915.39.3500
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View

PhysChem Properties

Material listed in food chemical codex No
Molecular weight 136.15016174316
Specific gravity @ 25 °C
Pounds per Gallon 8.928 to 8.978
Refractive Index 1.501 to 1.506 @ 20 °C
Boiling Point 196 to 198°C @ 760 mm Hg
Acid Value 1 max KOH/g
Vapor Pressure 0.418 mmHg @ 25 °C
Flash Point TCC Value 76.67 °C TCC
logP (o/w) 1.653 est
Shelf life 24 months (or longer if stored properly.)
Storage notes Store in cool, dry place in tightly sealed containers, protected from heat and light.
Solubility
alcohol Yes
water, 4639 mg/L @ 25 °C (est) Yes
water No

Organoleptic Properties

Odor Type: Phenolic
phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
Odor strength medium
Substantivity 6 hour(s) at 100.00 %
Luebke, William tgsc, (2021) At 10.00 % in dipropylene glycol. phenolic medicinal animal resinous castoreum woody smoky burnt
Flavor Type: Phenolic
phenolic, animal, resinous, castoreum, smoky, burnt, fecal
Luebke, William tgsc, (2021) Phenolic animal resinous castoreum smoky burnt fecal

Occurrences

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 36 - Wear suitable protective clothing.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Pictogram
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1630 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

Dermal Toxicity:
skin-rabbit LD50 8 ml/kg
Union Carbide Data Sheet. Vol. 11/4/1964.

Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
Click here to view publication 19
average usual ppmaverage maximum ppm
baked goods: 5.0000010.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: 1.000005.00000
granulated sugar: --
gravies: --
hard candy: 5.000007.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --

Safety references

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 88, (FGE.88)[1] - Consideration of Phenol and Phenol Derivatives - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
NIOSH International Chemical Safety Cards:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):122-79-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31229
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1993
WGK Germany:2
phenyl acetate
Chemidplus:0000122792
EPA/NOAA CAMEO:hazardous materials
RTECS:122-79-2