2-methoxypyridine

General Material Information

Preferred name	2-methoxypyridine
Trivial Name	2-Methoxypyridine
Short Description	pyridine, 2-methoxy-
Formula	C6 H7 N O
CAS Number	1628-89-3
FEMA Number	4639
ECHA Number	216-623-8
FDA UNII	GEB38J8108
Nikkaji Number	J7.535C
Beilstein Number	0108189
MDL	MFCD00006262
NMR Predictor	External link
JECFA Food Flavoring	2156 2-methoxypyridine
FDA Patent	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm	1628-89-3 ; 2-METHOXYPYRIDINE
Synonyms	2-methoxy pyridine methyl 2-pyridyl ether pyridine, 2-methoxy-

US / EU / FDA / JECFA / FEMA / Scholar / Patents

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Literature & References

	2-methoxypyridine
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	74201
Pubchem (sid):	135032872

Publications by US Patents
3,952,024 - Furfurylthioacetone
Certain 2,5-dimethyl-3-thiopyrazines
Publications by PubMed
Highly linear selective cobalt-catalyzed addition of aryl imines to styrenes: reversing intrinsic regioselectivity by ligand elaboration.
Triflic anhydride mediated synthesis of imidazo[1,5-a]azines.
HIV-1 associated Topoisomerase IIβ kinase: a potential pharmacological target for viral replication.
Development of new carbon-11 labelled radiotracers for imaging GABAA- and GABAB-benzodiazepine receptors.
Preparation of THP-ester-derived pyridinium-type salts and their reactions with various nucleophiles.
Deprotonative metalation of aromatic compounds by using an amino-based lithium cuprate.
Characterization of two hydroxytrichloropicolinic acids: application of the one-bond chlorine-isotope effect in 13C NMR.
In search of conformationally chiral square-planar complexes: dichloridobis(2-methoxypyridine-kappaN)copper(II).
Electron-transfer oxidation of coenzyme B12 model compounds and facile cleavage of the cobalt(IV)-carbon bond via charge-transfer complexes with bases. A negative temperature dependence of the rates.
Influence of two insecticides, chlorpyrifos and quinalphos, on arginine ammonification and mineralizable nitrogen in two tropical soil types.
Dissipation of chlorpyrifos in two soil environments of semi-arid India.
Lithiation of 2-chloro- and 2-methoxypyridine with lithium dialkylamides: initial ortho-direction or subsequent lithium ortho-stabilization?
Acid-base equilibria in nonpolar media. 2.(1) Self-consistent basicity scale in THF solution ranging from 2-methoxypyridine to EtP(1)(pyrr) phosphazene.
Lithiation of 2-heterosubstituted pyridines with BuLi-LiDMAE: evidence for regiospecificity at C-6.
A pyridone analogue of traditional cannabinoids. A new class of selective ligands for the CB(2) receptor.
Ethyl 6-amino-2-methoxypyridine-3-carboxylate, interplay of molecular and supramolecular structure.
Studies of the synthesis and thermochemistry of coordinatively unsaturated chelate complexes (eta 5-C5Me5)IrL2 (L2 = TsNCH2CH2NTs, TsNCH2CO2, CO2CO2).
An efficient synthesis of 5-bromo-2-methoxy-6-methylaminopyridine-3carboxylic acid.
cis-Dichloro(dimethyl sulfoxide-S)(2-methoxypyridine-N)platinum(II).
Synthesis and antiinflammatory activity of 6-oxo-1-(beta-D-ribofuranosyl)nocotinic acid and related derivatives.

Other Information

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEMBL:	View
HMDB (The Human Metabolome Database):	Search
Export Tariff Code:	2933.39.9100
ChemSpider:	View

Suppliers

Ambles Nature et Chimie	Beijing Lys Chemicals
BOC Sciences	M&U International
Penta International	Sigma-Aldrich: Aldrich
Sunaux International	TCI AMERICA
Tengzhou Jitian Aroma Chemiclal	Tianjin Danjun International
WholeChem	Beijing Lys Chemicals Co, LTD.
M&U International LLC	Penta International Corporation
Tianjin Danjun International Trade Co., LTD.	WholeChem, LLC

PhysChem Properties

Material listed in food chemical codex	No
Molecular weight	109.12799072266
Specific gravity	@ 20 °C
Pounds per Gallon	8.697 to 8.747
Refractive Index	1.501 to 1.507 @ 20 °C
Boiling Point	142 to 144°C @ 760 mm Hg
Vapor Pressure	7.114 mmHg @ 25 °C
Flash Point TCC Value	31.67 °C TCC
logP (o/w)	1.34
Solubility
alcohol	Yes
water, 7855 mg/L @ 25 °C (est)	Yes
water	No

Organoleptic Properties

Flavor Type: Burnt
burnt, mustard
General comment	Burnt, mustard-like

Safety Information

Safety information

Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/39 - Wear suitable clothing and eye/face protection.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in use information

Category:
flavoring agents
Recommendation for 2-methoxypyridine usage levels up to:
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
		average usual ppm	average maximum ppm
baked goods:		-	-
beverages(nonalcoholic):		-	-
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		-	-
fruit ices:		-	-
gelatins / puddings:		0.20000	5.00000
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	-
imitation dairy:		-	-
instant coffee / tea:		0.10000	2.00000
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		0.20000	5.00000

Safety references

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :74201

National Institute of Allergy and Infectious Diseases:Data

WISER:UN 1993

WGK Germany:3

2-methoxypyridine

Chemidplus:0001628893